3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE

Details:

Yinherb Lab Urolithin B Raw Powder 99% Purity 
Product name: Urolithin B 
Other name: 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE
CAS: 1139-83-9
Molecular Formula: C13H8O3
Assay: 98%
Appearance: White powder
Capacity: 500kgs per month
Source: synthetic
Purity (HPLC) >99.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years

What is Urolithin B?
Urolithin B is an urolithin, a type of phenolic compounds produced in the human gut after absorption of ellagitannins-containing food such as pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine. Urolithin B is found in the urine in the form of urolithin B glucuronide.


Urolithin B Benefits

Effect of Urolithin B  on cell proliferation, metastasis, and MMP‐9 activity. SW620 cells were treated with 0 (a) 0.15 (b) 1.5 (c) or 15 (d) µM urolithin A for 24 h (A) and cell proliferation was measured using MTT assay (B). Photographs (×100 magnification) are representative of three independent experiments. Cell monolayers were wounded using 200 µL pipette tips, treated with 0 (a) 0.05 (b) µM urolithin A for 48 h and photographs were taken (×100 magnification) to measure cell migration (C). After treatment with 0 (a) 0.05 (b) µM urolithin A for 48 h, cells were seeded above transwell chamber membranes. After 4 h, membrane bottoms were stained with crystal violet and photographs were taken (×200 magnification) to assess cell invasion (D). MMP‐9 activity was determined by MMP assay in cells treated with 0.05 µM urolithin A for 48 h (E) *P < 0.05 represents significant difference from the control group.

Urolithin B Mode of Action

Urolithins are microflora human metabolites of dietary ellagic acid derivatives such as ellagitannins. They are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine.

During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo in humans. Urolithins metabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice.

Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites. Urolithins are found in plasma mostly as glucuronides at low concentrations.

Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella.

Urolithin B HPLC &NMR Test report by Yinherb 

FAQ
Q1: Can i get some samples 
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
 
Q2: How to start orders or make payments 
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, or Paypal or Escrow(Alibaba).
 
Q3: How to confirm the Product Quality before placing orders 
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
 
Q4:What's your MOQ 
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
 
Q5: How about delivery leadtime 
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
 
Q6:Is there a discount 
A:Different quantity has different discount.
 
Q7: How do you treat quality complaint 
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.