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Andrographolide CAS:5508-58-7  Andrographis Paniculata Extract

 

Product Name:Andrographolide

Synonyms:ent-(3β,12E,14R)-3,14,19-Trihydroxy-8(17),12-labdadien-16,15-olide;Andrographolide/Andrographis Paniculata P.E.;5-alpha,6-alpha,8a-alpha))-t;2(3h)-furanone,3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-met;3-(2-(Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene- 1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5- alpha,6-alpha,8a-alpha))-2(3H)-furanone;(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-1,2,3,4,4a,5,6,7,8,8a-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthalene-1-yl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone;(S)-3-[(E)-2-[[(1R,4aα)-Decahydro-6β-hydroxy-5β-hydroxymethyl-5,8aβ-dimethyl-2-methylenenaphthalen]-1β-yl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone;Andrographolid

CAS:5508-58-7

MF:C20H30O5

MW:350.45

EINECS:226-852-5

Melting point:229-232 °C (lit.)

alpha:-126 º (c=1.5,HAc)

Boiling point:557.3±50.0 °C(Predicted)

density:d421 1.2317

storage temp.:2-8°C

solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 8 mg/ml).

form:Off-white solid

Stability:Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

 

 

Description   

Andrographolide is the bitter principle, a colorless and neutral crystalline substance. It is the major labdane diterpenoid isolated from Andrographis paniculate. It exhibits antiviral, anti-inflammatory, and anticancer activities. The underlying mechanism is the inhibition of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling (specifically p38 MAPK/ERK1/2) pathway and downstream transcription factors such as nuclear factor kappa B (NF-κB) and nuclear factor of activated T cells (NFAT). Andrographolide is also confirmed with chemopreventive effects against and the inhibitory effects on cancer cell growth in breast, colon, epidermoid, gastric, liver, leukemia, myeloma, peripheral blood lymphocytes, and prostate cancers.

Andrographolide has been used for liver complaints and fever, and as an anti-inflammatory and immunostimulant. Andrographolide exerts anti-growth and pro-apoptotic effects on human rheumatoid arthritis fibroblast- like synoviocytes, the main cellular constituent of pannus, that combined with a massive infiltration of lymphocytes and macrophages, invades and destroys the local articular structure. Thereby, andrographolide is proposed to be used in Rheumatoid Arthritis and other autoimmune diseases.

 

 

 

 

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Packing:20kg/carton,22kg/carton,25kg/drum,etc
Shipping:by sea or by air
Payment:T/T,,moneygram,bitcoin

Small quantity	Aluminium bag, inside two level plastic bags(1KG or less/Aluminium bag)
Bulk quantity	25kg/drum, inside two level plastic bags
Others	can do your package or split small packages according to your request
	Moisture-proof Plastic Bags Aluminum Foil Bag 5KG/10KG/25KG/45KG/180kg Drums

 

Shipping:

By Courier: Fedex, EMS, DHL, TNT, UPS, etc. 7-10 days product will reach you after payment received,  if it's agreed as ready stock before order.

By air, airport to airport

By sea

 

Company Information

Hebei Mojin Biotechnology Co., Ltd, our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.