- Min.Order :1 Kilogram
- Purity: USP/EP/BP
- Payment Terms : L/C,T/T,Other
Keywords
Benzamide,N-(2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-,[9S-(9a,10b,11b,13a)]- 120685-11-2 Midostaurin
Quick Details
- Appearance:White crystallization
- Application:oral anticoagulant drug
- PackAge:25kg/drum
- ProductionCapacity:10|Metric Ton|Day
- Storage:room temperature
- Transportation:AIR SEA TRAIN
Superiority:
| Product Name: | Midostaurin |
| Synonyms: | CGP 41251MIDOSTAURIN(PKC412);N-((5S,6R,7R,9R)-6-Methoxy-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-Methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-MethylbenzaMide;PKC-412, CGP-41251;Midostaurin (PKC412);PKC412 (Midostaurin);CGP 41231;N-Benzoylstaurosporine;(Midostaurin) Benzoylstaurosporine |
| CAS: | 120685-11-2 |
| MF: | C35H30N4O4 |
| MW: | 570.64 |
| EINECS: | 999-999-2 |
| Product Categories: | antibiotic;Pharmaceutical |
| Mol File: | 120685-11-2.mol |
| Midostaurin Chemical Properties |
| Melting point | 235-260℃ |
| density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml). |
| form | Tan solid |
| pka | 14.19±0.70(Predicted) |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 36/37/38 |
| HS Code | 29329990 |
Details:
| Description | PKC-412 (120685-11-2) is a broad spectrum kinase inhibitor. Inhibited kinases include, but are not limited to; PKA, PKC, S6 Kinase, KDR, PKC, Akt, EGFR, VEGFR, PDGFR, c-kit, and FLT-3. Acute myeloid leukemia related mutant forms of FLT-3 are also inhibited both in vitro and in vivo. PKC-412 has been demonstrated to induce apoptosis and shows broad antiproliferative activity in various tumor cell lines. Cell Permeable |
| Uses | Midostaurin is used as a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Due to this act which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors. Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit. |
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