Quinazoline,2-(chloroMethyl)-4-Methyl-

Details:

Common name: 2-(chloromethyl)-4-methylquinazoline

Category:Linagliptin intermediates

Other name: Quinazoline,2-(chloroMethyl)-4-Methyl-

CAS No.: 109113-72-6

EINECS No.: 476-280-7

Appearance: Powder

Molecular formula: C10H9ClN2

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	192.64
Boiling point	240.0±32.0 °C(Predicted)
Melting point	61.0 to 65.0 °C
Density	1.251
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	1.86±0.50(Predicted)
Soluble	Soluble in chloroform (a little), methanol (a little)
Water solubility	3.11g/L at 20°C
Color	Light yellow

 

 

Product Description:
2-(Chloromethyl)-4 - methylquinazoline typically appears as a colorless to light - yellow crystalline solid. Structurally, it features a quinazoline ring system, which consists of a benzene ring fused with a pyrimidine ring. At the 2 - position, there is a chloromethyl group (-CH?Cl), and a methyl group is attached at the 4 - position. The chloromethyl group is highly reactive due to the electronegativity of the chlorine atom, which makes the carbon atom in the -CH?Cl moiety susceptible to nucleophilic substitution reactions. The methyl group at the 4 - position can influence the electron density of the ring system, affecting its reactivity and physical properties.

In terms of solubility, it has low solubility in water, mainly because of the non - polar nature of the quinazoline ring. However, it shows better solubility in common organic solvents such as dichloromethane, chloroform, and ethyl acetate. Under normal storage conditions, it is relatively stable. But when exposed to strong nucleophiles, the chlorine atom in the chloromethyl group can be easily replaced, leading to the formation of new compounds. High temperatures and strong oxidizing or reducing agents can also cause decomposition or unwanted chemical reactions.

In the field of organic synthesis, 2-(Chloromethyl)-4 - methylquinazoline serves as a crucial building block. It can be used to synthesize a wide range of quinazoline - based derivatives by reacting with various nucleophiles, such as amines, thiols, and alkoxides. In pharmaceutical research, it is of great interest as quinazoline - based compounds often exhibit diverse biological activities. For example, it may be a potential intermediate for the synthesis of drugs targeting specific biological pathways related to cell growth, proliferation, or signal transduction. To maintain its quality and reactivity, it should be stored in a cool, dry place, away from light, moisture, and strong nucleophiles, as these factors can trigger unwanted reactions and degrade the compound.

 

Application: 

An intermediate of Lilalitine

Package: 25kg/drum or bag

Storage: Under inert gas (nitrogen or Argon) at 2–8 °C

Executive Standards: International Standard.