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84625-61-6 cas 84625-61-6 Itraconazole
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Product name | Itraconazole | |
CAS No. | 84625-61-6 | |
MF | C35H38Cl2N8O4 | |
MW | 705.63 | |
EINECS | 617-596-9 |
Product Name: Itraconazole | ||||
CAS No.: 84625-61-6 | ||||
Batch No.: ACT20231226 | Quantity (Net weight):2.0Kgs | |||
Inspection characteristic | Specification | Test result | ||
Appearance | White to almost white power | Conform | ||
Identification | IR | Conform | ||
Optical Rotation (20°) | -0.10° to +0.10° | Conform | ||
Melting range | 166ºC-170ºC | 166ºC-169ºC | ||
Related substances | Impurity 1 | 0.50%max | Conform | |
Impurity 2 | 0.50%max | Conform | ||
Impurity 3 | 0.50% max | Conform | ||
Impurity 4 | 0.50%max | Conform | ||
Impurity 5 | 0.50%max | Conform | ||
Impurity 6 | 0.50%max | Conform | ||
Impurity 7 | 0.50%max | Conform | ||
Unspecified Impurities | 0.10%max | Conform | ||
Total impurities | 1.25%max | 0.81% | ||
Loss on drying | 0.50%max | 0.34% | ||
Residue on ignition | 0.10%max | 0.05% | ||
Assay | 98.5.0%-101.5% | 99.1% |
Description:
Itraconazole is a synthetic triazole derivative. It is a synthetic broad-spectrum antifungal drug. Its antibacterial spectrum and antibacterial mechanism are similar to clotrimazole, but it has strong antibacterial activity against aspergillus. By changing the Chemicalbook permeability of fungal cell membrane, itraconazole exerts antibacterial activity against pathogens of superficial and deep fungal infections. Its antibacterial spectrum is wider and stronger than ketoconazole, and it can inhibit the synthesis of ergosterol in fungal cell membrane, so as to exert antifungal effect.
Use:
Imidazole antifungal agents of triazole ring. By preventing the activation of cytochrome P-450 including oxidase and peroxidase, 14, α-methylsterol can not be dehydrogenated, can not be converted into ergosterol, so that the growth and proliferation of fungi is inhibited, has a strong lipophilicity, can pass through the biofilm, inhibit the combination of membrane and fungus. Its antibacterial profile is similar to ketoconazole. It is effective for superficial fungal diseases such as vaginal and oral candidiasis and dermatomycosis, and is expected to become an efficient and safe drug for deep fungal infections such as cryptococcal encephalitis (AIDS). It is used for vulvovaginal candidiasis, pityriasis variegata and cutaneous mycosis caused by sensitive fungi.
Package:
Packing: 20kg/carton,or at your requirment.
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Shelf Life: 24 months when properly stored.
Storage: Store in Cool and dry place,keep away from strong light,hight temperature.
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