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CAS No. 53-84-9 Adenine-nicotinamide dinucleotide NAD+
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Details:
NAD+ (Nicotinamide Adenine Dinucleotide)
1. Central Role in Energy Metabolism
NAD+ acts as a critical coenzyme, driving cellular energy production through electron transfer:
- Participates in glycolysis, the tricarboxylic acid (TCA) cycle, and the mitochondrial respiratory chain to promote ATP synthesis¹??.
- Regulates energy release during fatty acid oxidation, maintaining metabolic homeostasis??.
2. DNA Repair & Genome Stability
- Serves as a substrate for PARP enzymes, supporting base excision repair and single-strand break repair to reduce DNA damage accumulation¹??.
- Maintains telomere integrity, delaying age-related genomic instability??.
3. Anti-Aging & Disease Regulation
- Age-related decline in NAD+ levels leads to mitochondrial dysfunction, metabolic decline, and accelerated aging??.
- Activates sirtuins (SIRT1–SIRT7) via deacetylation, modulating gene expression to delay neurodegenerative (e.g., Alzheimer’s) and cardiovascular diseases???.
4. Reproductive Health
- Supports testosterone synthesis and male fertility by regulating cholesterol-metabolizing enzymes.
5. Redox Balance
- Maintains cellular redox homeostasis through the NAD+/NADH cycle, reducing oxidative stress.
Mechanistic Overview
NAD+ sustains cellular functions through energy metabolism, DNA repair, and epigenetic regulation. Its decline is directly linked to aging and metabolic disorders. Supplementation with precursors (e.g., NMN) can partially restore physiological functions.
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