N-(1,1-Dimethylethyl)-3-[[5-methyl 936091-26-8

Details:

Molecular Formula	C27H36N6O3S
Molar Mass	524.68
Density	1.247
Melting Point	180-182°C
Boling Point	713.7±70.0 °C(Predicted)
Flash Point	385.5 °C
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Beige powder.
Color	White to Off-White
pKa	11.95±0.50(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
In vitro study	TG-101348 also significantly inhibited JAK2 V617F, Flt3 and Ret,IC50 at 3 nM, 15 nM and 48 nM, respectively. TG101348 is more than 300 times higher than the IC50 of closely related JAK3, and has little inhibitory effect on JAK1 and TYK2 families. TG101348 inhibits the proliferation of a human erythroleukemia cell line with the JAK2V617F mutation and a mouse pre-B cell line expressing human JAK2V617F (Ba/F3 JAK2V617F) with IC50 of 305 nM and 270 nM, respectively. G-101348 also inhibited the proliferation of parental Ba/F3 cells to a normal level with an IC50 of about 420 nM. The concentration at which TG101348 reduced STAT5 phosphorylation was consistent with the concentration required to inhibit cell proliferation. TG101348 induced apoptosis of HEL and JAK2V617F Ba/F3 cells in a dose-dependent manner. TG101348 has no pro-apoptotic activity on normal human dermal fibroblasts at concentrations up to 10 μm. TG101348 reduced the expression of GATA-1, which and erythroid-skewing JAK2V617F TG101348 inhibited the proliferation of HMC-1.1(KITV560G) cells, the activity was lower than that of HMC-1.2 (KITD816V, KITV560G) cells, and the IC50 was 740 nM and 407 nM, respectively.
In vivo study	TG101348 has the potential to treat jak2v617f-related myeloproliferative disorders (MPD). Statistically significant reductions in hematocrit and white blood cell counts in TG101348 treated animals, with a dose-dependent reduction/elimination of extramedullary hematopoiesis, at least in some cases, manifested by attenuating myelofibrosis, there are surrogate endpoints, including reduction/elimination of JAK2V617F disease burden, inhibition of endogenous erythrocyte colony formation associated with inhibition of JAK-STAT signaling in vivo. There was no apparent toxicity and no effect on T-cell numbers. Oral administration of TG101348(120 mg/kg) significantly inhibited photovoltaic erythroid progenitor cell differentiation in vivo.

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

Superiority
As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, toll/contract manufacture, investment solution and suitable partnership establishment in China.
Service we can provide:
1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
5.Mix and different products in ONE PCL,increase the working efficiency for customers.
6.We can export from many China main ports,convenient for the customes provide logistics services.
Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

FAQ: 
1.Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3.How long is lead time  
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located How can I visit the factory   
 Our factory located in HEBEI, China.

5.Can i get some samples 
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6.How to start orders or make payments 
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders 
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

9.How do you treat quality complaint

First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.