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Bethanechol 1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-,chloride (9CI) 590-63-6
We are very compeitive on Bethanechol.Our mfr is GMP certified for this item with DMF document.
Product Name: | Bethanechol |
Synonyms: | (2-hydroxypropyl)trimethylammoniumchloridecarbamate;2-((aminocarbonyl)oxy)-n,n,n-trimethyl-1-propanaminiuchloride;2-[(aminocarbonyl)oxy]-n,n,n-trimethyl-1-propanaminiuchloride;ammonium,(2-hydroxypropyl)trimethyl-,chloride,carbamate;beta-methylcholinechlorideurethan;bethainecholinechloride;carbaminoyl,beta-methylcholinechloride;carbamyl-b-methylcholinechloride*crystalline |
CAS: | 590-63-6 |
MF: | C7H17ClN2O2 |
MW: | 196.68 |
EINECS: | 209-686-8 |
Product Categories: | Coumarins ,Pyrans;Inhibitors;DUVOID;Acetylcholine receptor;Aliphatics;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;590-63-6 |
Mol File: | 590-63-6.mol |
Bethanechol Chemical Properties |
Melting point | 187-190°C |
storage temp. | Inert atmosphere,2-8°C |
solubility | H2O: 1.7 g/mL stable for several days at 4°C. |
form | crystalline |
color | white |
Water Solubility | H2O: 1.7g/mL (stable for several days at 4°C.) ethanol: 80mg/mL (stable for several days at 4°C.) |
Bethanechol Usage And Synthesis |
Description | Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 μM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol in isolated guinea pig small intestine (IC50 = 127 μM). Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 μM). It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 μg/kg. Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract. |
Chemical Properties | White Solid |
Originator | Urecholine CI,MSD,US,1949 |
Uses | cholinergic |
Uses | A selective muscarinic receptor stimulant, used to treat cerebral palsy. |
Uses | Therapeutic action of Betanechol is based on this action, and it is used for treating postoperational non-obstructive retention of urine and neurogenic bladder atony. Earlier, it was used for treating gastrointestinal illnesses and Alzheimer’s disease. |
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