Clofarabine

Clofarabine

Clofarabine

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 99%
  • Payment Terms : L/C,T/T

Keywords

Clofarabine 2-chloro-6-aminopurine 2-deoxy-2-fluoro-1,3,5-tribenzoate-alpha-d-arabinofuranose

Quick Details

  • Appearance:
  • Application:intermediates
  • PackAge:25KG
  • ProductionCapacity:|Metric Ton|Day
  • Storage:
  • Transportation:by air,by sea

Superiority:

 

 

 

Shanghai Micro-mega Industry Co., LTD  is a comprehensive enterprise with research and development,             

production, sales and import and export business.  

The business covers the pharmaceutical and polymer composite materials, and has established a long-term cooperation and business relationship with domestic, foreign enterprises and research institutions.

Our pharmaceutical intermediates business is focused on anti-cancer, antiviral, ribose and nucleoside derivatives from R & D to customized, production.

Details:

Product Name: Clofarabine
Synonyms: 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE;5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol;CLOFARABINE;CAFDA;2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine;Clolar
CAS: 123318-82-1
MF: C10H11ClFN5O3
MW: 303.68
EINECS:  
Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Bases & Related Reagents;Nucleotides;Pharmaceutical intermediate;CLOLAR;Antineoplastic;Anti-cancer&immunity
Mol File: 123318-82-1.mol

mp  228-2310C
storage temp.  Desiccate at +4°C
CAS DataBase Reference 123318-82-1(CAS DataBase Reference)

Chemical Properties White Solid
Usage ISecond generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic
Biological Activity Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
 

 

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