- Min.Order :1 Kilogram
- Purity: 99%
- Payment Terms : L/C,T/T
Keywords
Clofarabine 2-chloro-6-aminopurine 2-deoxy-2-fluoro-1,3,5-tribenzoate-alpha-d-arabinofuranose
Quick Details
- Appearance:
- Application:intermediates
- PackAge:25KG
- ProductionCapacity:|Metric Ton|Day
- Storage:
- Transportation:by air，by sea
Superiority:
Shanghai Micro-mega Industry Co., LTD is a comprehensive enterprise with research and development,
production, sales and import and export business.
The business covers the pharmaceutical and polymer composite materials, and has established a long-term cooperation and business relationship with domestic, foreign enterprises and research institutions.
Our pharmaceutical intermediates business is focused on anti-cancer, antiviral, ribose and nucleoside derivatives from R & D to customized, production.
Details:
| Product Name: | Clofarabine |
| Synonyms: | 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE;5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol;CLOFARABINE;CAFDA;2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine;Clolar |
| CAS: | 123318-82-1 |
| MF: | C10H11ClFN5O3 |
| MW: | 303.68 |
| EINECS: | |
| Product Categories: | Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Bases & Related Reagents;Nucleotides;Pharmaceutical intermediate;CLOLAR;Antineoplastic;Anti-cancer&immunity |
| Mol File: | 123318-82-1.mol |
| mp | 228-2310C |
| storage temp. | Desiccate at +4°C |
| CAS DataBase Reference | 123318-82-1(CAS DataBase Reference) |
| Chemical Properties | White Solid |
| Usage | ISecond generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic |
| Biological Activity |
Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors. |
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