Vildagliptin 274901-16-5
Q2 2013
Vildagliptin (previously identified as LAF237, trade names Zomelis, Galvus) is anal anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitclass of drugs. Vildagliptin inhibits the inactivation of GLP-1[2][3] GIP[3] by DPP-4, allowing GLP-1 GIP to potentiate the secretion of insulin in the beta cells suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas.
Vildagliptin has been shown to reduce hyperglycemia in type 2 diabetes mellitus.
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