Add time:07/23/2019         Source:sciencedirect.com

The bioactive substance investigation of Balanophora involucrata obtained 15 phenolic acids, including 5 new compounds (1–3, 8, 9), which were determined by various spectroscopic data analyses. Most isolated compounds displayed inhibitory effects on α-Glucosidase in vitro. For the potential inhibitors 8 (1.95 μM) and 10 (9.02 μM), the inhibition kinetics have been studied, which gave the Ki values as 0.68, 3.15 μM respectively. And, in silico docking analyses have been performed to investigate the inhibitory mechanism of compounds 8 and 10. Additionally, most isolated compounds showed anti-oxidant activities in the DPPH scavenging assay. New compound 8 also could inhibit the acetyl transfer activity of GlmU moderately with the IC50 value of 18.21 μM, which was a new antibacterial target.

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