Add time:07/24/2019         Source:sciencedirect.com

Hydrazides and their solid complexes demonstrate biological and pharmacological activity. The present study determines the hitherto undescribed coordinating properties of three hydrazides (Acethydrazide (cas 1068-57-1), formic hydrazide and oxalodihydrazide) towards copper(II) in aqueous solutions by means of various potentiometric (ISE, pH-metric) and spectroscopic (UV–Vis, EPR) methods. The speciation models are than confirmed by ESI-MS. Due to metal-promoted deprotonation, the complexes are formed below pH 2 and coordination occurs with one, two or three ligand molecules. EPR spectroscopy revealed bidentate {N,O} coordination, leading to a five-membered chelate ring. Dissociation of the amide protons occurs only for acethydrazide by enolization which allows the formation of a complex with a twice-deprotonated ligand molecule. For the copper(II) systems with oxalodihydrazide and formic hydrazide, the amide groups of the ligands remain protonated, as the appearance of a precipitate at low pH limits further measurements.

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