Synthesis and anticancer activities of thieno[3,2-d]pyrimidines as novel HDAC inhibitors-Science-Chemical Encyclopedia-lookchem

Synthesis and anticancer activities of thieno[3,2-d]pyrimidines as novel HDAC inhibitors
Add time:07/29/2019 Source:sciencedirect.com

A series of thieno[3,2-d]pyrimidines bearing a hydroxamic acid moiety as novel HDAC inhibitors were designed and synthesized. The structures of the new synthesized compounds were confirmed using IR, 1H, 13C NMR spectrum. Compounds 11–13 showed potent inhibitory activities against HDACs with IC50 values at 0.38, 0.49 and 0.61 μM. Most of target compounds displayed strong anti-proliferative activity by a MTT assay on three human cancer cell lines including HCT-116, MCF-7 and HeLa. Compound 11, having potent inhibitory activities against HDACs, induced apoptosis and G2/M cell cycle arrest in HCT-116 cell line.

We also recommend Trading Suppliers and Manufacturers of 2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine (cas 16234-15-4). Pls Click Website Link as below: cas 16234-15-4 suppliers

Prev:Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine and quinazoline derivatives as potent antitumor agents
Next: Synthesis, anticancer activity and effects on cell cycle profile and apoptosis of novel thieno[2,3-d]pyrimidine and thieno[3,2-e] triazolo[4,3-c]pyrimidine derivatives)

Click to view details

Encyclopedia