Add time:07/30/2019         Source:sciencedirect.com

Colloidal dispersions of polycyclic aromatic hydrocarbons were found to inhibit glyceraldehyde-3-phosphate dehydrogenase (GPDH) and lactic acid dehydrogenase (LDH) after a short exposure of the incubation medium to laboratory lighting. The activation effect was observed with substituted 7-methyl derivatives of 12-methylbenz(a)anthracene also. One minute exposure of 7-methoxy methyl-12-methylbenz (a)anthracene (MeO-DMBA) to light was sufficient to produce a measurable amount of GPDH inhibition. The rate of enzyme inhibition was related to the pH of the dispersion.A small but significant effect of light on the inhibition of the enzymes by K-region epoxides was seen. Protein binding of the epoxides was not well correlated with the inhibition.The light effect was oxygen-dependent and was related to the hydrocarbon concentration. The active form decayed over a period of more than 25 days. The necessity for protecting reactions involving hydrocarbons and their derivatives from light is emphasized.

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