Add time:07/30/2019 Source:sciencedirect.com
The three-dimensional solid-state structures of Prazosin hydrochloride (cas 19237-84-4), C19H22N5O4+ · Cl− (A), and prazosin free base, C19H21N5O4 (B), have been determined by synchrotron X-ray powder diffraction. A and B crystallize in triclinic P-1 and monoclinic Cc space groups, respectively, with one structural unit per asymmetric part. In A and B, the prazosin molecule adopts different conformations, which do not correspond to those obtained by DFT optimizations of protonated and free prazosin. © 2004 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:3090–3095, 2004
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