Add time:07/31/2019         Source:sciencedirect.com

Publisher SummaryThis chapter discusses the prazosin hydrochloride. Prazosin hydrochloride was synthesized and developed by the Medicinal Chemistry Laboratories of Pfizer Inc. Prazosin hydrochloride was introduced as a novel antihypertensive agent with pharmacological activity attributed to arteriolar vasodilation. The anhydrous alpha form is the preferred polymorphic form of prazosin hydrochloride due to its nonhygroscopic characteristic leading to ease of handling and formulation. The prazosin hydrochloride alpha polymorphic form was used throughout the clinical efficacy studies. Its trade names are minipress, hypovase, and sinetens. Prazosin hydrochloride is a white to off-white, crystalline, odorless powder. The infrared absorption spectrum of prazosin hydrochloride was obtained as a KBr pellet using a Perkin-Elmer model 21 infrared spectrophotometer.

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