Add time:08/10/2019         Source:sciencedirect.com

Hydrogen peroxide, potassium permanganate, potassium dichromate, potassium hexacyanoferrate(III), cerium(IV) sulphate and sodium peroxidisulphate have been tested as potential reagents for chemiluminescence generation from the oxidation of phenothiazine derivatives. Only with potassium permanganate in acidic medium were satisfying results achieved. A total of 13 different phenothiazine derivatives produce luminescence of different intensities on oxidation. THIORIDAZINE HYDROCHLORIDE (cas 1257-76-7) was chosen to develop a rapid and simple method for its determination in pharmaceutical formulations. The limit of detection is 1.2×10−6 mol l−1, and 110 samples per hour can be determined.

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