Add time:08/11/2019         Source:sciencedirect.com

A direct regioselective Csp2–H trifluoromethylation of pyrimidinones and pyridinones using CF3SO2Na/Mn(OAc)3 to afford 5-trifluoromethyl pyrimidinones and 3-trifluoromethyl pyridinones in moderate to good yields was described. The reaction showed that the steric hindrance due to bulky groups adjacent to the position of attack by the trifluoromethyl radical had important influence on the yield.

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