Add time:08/19/2019         Source:sciencedirect.com

PRIMYCIN (cas 113441-12-6) is a natural complex, a mixture of homologous antibiotics. On thin-layer chromatography in neutral solvent systems the co-crystallizing components exhibit the phenomenon of secondary adsorption. The complex can be separated in n-butanol or chloroform solvent systems containing a high percentage of organic acids by spots obtained by chemical detection. Detection by vanillin-sulphuric acid and by the Sakaguchi method was modified. The three main components of primycin (A1, A3 and B) are Sakaguchi-positive and their proportions are in good agreement with those of homogenous permethyl products prepared from primycin sulphate for structural studies. Quantitative data for the base crystallized from methanol or dimethylformamide are different from those for the genuine sulphate. The genuine main components were separated for the first time by repeated preparative thin-layer chromatography. Their biological activities were different, the akali labile A3 component being the most active.

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