Add time:08/15/2019         Source:sciencedirect.com

Three week-old rainbow trout hatchlings (Oncorhynchus mykiss) were exposed to 0.5 μg/l or 2.0 μg/l bis(tri-n-butyltin)oxide (TBTO) for 21 days in a flowthrough system. After 7 and 21 days, tissue samples of the brain (tectum opticum and optic nerve) were taken and processed for electron microscopical investigations. Ultrastructural lesions in the tectum opticum and the optic nerve included: intramyelin vacuolization in the stratum opticum and the stratum album centrale of the tectum opticum and also in the optic nerve; darkening of fibres in the stratum opticum of the tectum opticum; necrosis in regions of myelinated and non-myelinated fibres in the stratum opticum and stratum album centrale; and an increase in the number of dark cells in the stratum periventriculare of the tectum opticum. In animals treated for 21 days with 2 μg/l TBTO, tin could be identified in endothelial cells and myelin sheaths by means of electron spectroscopic imaging (ESI) and electron energy loss spectroscopy (EELS).

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