Add time:08/18/2019         Source:sciencedirect.com

In healthy women, there was a 41 per cent fall in plasma bradykininogen (cas 12642-94-3) 48 (36 to 60) hours before ovulation. Similarly, guinea pigs showed a 79 per cent fall 24 (18 to 30) hours before ovulation; recovery of normal values occurred by the time of ovulation itself. The 59 per cent fall in rats took place 17 (15 to 20) hours before ovulation. The fall persisted in women using oral contraceptives containing norethindrone and mestranol (1.0:0.05 to 2.0:0.1 mg. per day); a 39 per cent fall occurred 48 hours before the calculated time of “ovulation”. The women using oral contraceptives showed a 38 per cent elevation in plasma bradykininogen levels throughout the rest of the cycle, as compared with normal women. The fall in kininogen could not be found in early postmenopausal women or in control male guinea pigs. The results show that the fall in plasma bradykininogen is essentially a preovulatory change; the possibilities that it is linked to early events in the mechanism of ovulation and that it is associated with a rhythmic mechanism more fundamental than the events obstructed by the oral contraceptives are discussed.

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