Add time:08/20/2019         Source:sciencedirect.com

SummaryThe pressure-temperature phase diagram of the dimorphism of racemic M-NISOLDIPINE (cas 113578-26-0) is constructed using temperatures and enthalpies of fusion of forms A and B. At ordinary pressure, the transition from form B to form A is found to occur around 192 K, which indicates that these polymorphs are enantiotropically related and that form A is stable at room temperature. Nevertheless, the phase relationship turns to be monotropic when pressures become greater than about 100 MPa, which indicates that form B becomes the sole stable phase.

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