Add time:08/24/2019         Source:sciencedirect.com

The subchronic toxicity following oral administration of Dodine was studied in male and female rats. Animals received 5, 10, or 20 mg/kg of the product suspended in carboxymethyl cellulose daily for 90 days. Control animals received 10 ml/kg of the vehicle. No clinical signs of toxicity were observed in the treated animals. The body weight changes were slightly higher in the Dodine-treated animals than in controls of both sexes. The males receiving the lowest dose showed a marked increase in urea. There was a significant decrease in the aspartate amino transferase activity and bilirubin content of the males treated with the highest dose. Severe histological changes were found in heart, liver, and kidneys at the three doses in both sexes.

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