Add time:08/28/2019         Source:sciencedirect.com

The prodrug clopidogrel hydrochloride is an irreversible inhibitor of platelet aggregation that must be converted by liver enzymes to an active thiol constituent. The activity of the active thiol product is mediated through the irreversible inhibition of purinergic P2Y12 adenosine diphosphate (ADP) receptors on the surface of platelets. Clopidogrel is indicated for the prophylactic treatment of atherosclerosis in those who have suffered a stroke, myocardial infarction, have peripheral arterial disease, or have received a stent. This agent has been compared to many other antiplatelet drugs and has been demonstrated to be comparable to aspirin in its duration of action and efficacy.

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