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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 113665-84-2 Clopidogrel

Cas:113665-84-2

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Clopidogrel Cas 113665-84-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum

Chinese supplier Clopidogrel Cas 113665-84-2 with high quality and best price

Cas:113665-84-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Clopidogrel 113665-84-2 GMP Manufacturer

Cas:113665-84-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Clopidogrel

Cas:113665-84-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Clopidogrel

Cas:113665-84-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Clopidogrel

Cas:113665-84-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Clopidogrel Basic information Product Name: Clopidogrel Synonyms: CLOPIDOGREL;methyl (2s)-2-(2-chlorophenyl)-2-(9-thia-4-azabicyclo[4.3.0]nona-7,10-dien-4-yl)acetate;ClopidogrelHydrobrom

Clopidogrel 113665-84-2

Cas:113665-84-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 113665-84-2 Clopidogrel

Cas:113665-84-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 113665-84-2 with competitive price

Cas:113665-84-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

113665-84-2 Clopidogrel product Name Clopidogrel Synonyms methyl (2s)-2-(2-chlorophenyl)-2-(9-thia-4-azabicyclo[4.3.0]nona-7,10-dien-4-yl)acet

Clopidogrel,113665-84-2

Cas:113665-84-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & d

White Crystal Anticoagulant Drugs Clopidogrel Medication 113665-84-2

Cas:113665-84-2

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Clopidogrel 113665-84-2

Cas:113665-84-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Clopidogrel CAS:113665-84-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Clopidogrel CAS:113665-84-2

Cas:113665-84-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Clopidogrel

Cas:113665-84-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Factory High quality &low price Clopidogrel

Cas:113665-84-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Clopidogrel

Cas:113665-84-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd,Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all em

Raw Material API Clopidogrel CAS 113665-84-2

Cas:113665-84-2

Min.Order:1 Gram

FOB Price: $100.0

Type:Trading Company

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Clopidogrel

Cas:113665-84-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Clopidogrel

Cas:113665-84-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Clopidogrel CAS 113665-84-2

Cas:113665-84-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

White Crystal Anticoagulant Drugs Clopidogrel Medication 113665-84-2

Cas:113665-84-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Clopidogrel

Cas:113665-84-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

113665-84-2 Clopidogrel Appearance:white powder Storage:room temperature Package:according to customers' requirements Application:Pharma intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or a

113665-84-2 Clopidogrel

Cas:113665-84-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Clopidogrel

Cas:113665-84-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate

(S)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate Chlopidogrel

Cas:113665-84-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Clopidogrel

Cas:113665-84-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Clopidogrel Hydrogen Sulfate CAS No.:113665-84-2 Molecule Formula:C16H16ClNO2S Molecule Weight:321.82 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard T

Best Quality Clopidogrel Hydrogen Sulfate with good supplier

Cas:113665-84-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualified

Clopidogrel

Cas:113665-84-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Clopidogrel

Cas:113665-84-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

MOQ: 1kg Form: Powder Colour: White Test: HPLC Function: anti antiviral Grade: Pharm Appearance:white Storage:room Package:drum Application:anti anticoagulant Por

99% Edoxaban

Cas:113665-84-2

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Synthetic route

methyl-(S)-alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate camphor sulphonate

methyl-(S)-alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate camphor sulphonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water Product distribution / selectivity;100%
With sodium hydrogencarbonate In dichloromethane; water at 15 - 20℃; pH=7 - 8; Product distribution / selectivity;
With sodium hydrogencarbonate In chloroform; water for 2h;
(S)-(+)-clopidogrel bisulfate
120202-66-6

(S)-(+)-clopidogrel bisulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water at 15℃; for 0.333333h;100%
With ammonia In hexane; water at 25 - 30℃; pH=7;97.86%
With sodium carbonate In dichloromethane; water at 20℃; for 0.5h; Large scale;92%
clopidogrel camphorsulfonate
909279-85-2

clopidogrel camphorsulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium carbonate In tert-butyl methyl ether; water at 20℃; for 0.5h; Solvent;100%
With sodium hydrogencarbonate In dichloromethane; water at 25 - 30℃; for 0.166667h; Product distribution / selectivity;
With potassium carbonate In dichloromethane; water for 1h; pH=9; Product distribution / selectivity; cooling with cool salt water;
clopidogrel camphorsulfonate

clopidogrel camphorsulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium carbonate In tert-butyl methyl ether; water for 0.5h; Solvent;100%
With sodium hydrogencarbonate In acetone for 6h; Reflux;
clopidogrel (1R)-(-)-camphor-10-sulfonate

clopidogrel (1R)-(-)-camphor-10-sulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane at 0 - 5℃; for 1h;99.2%
With potassium carbonate In dichloromethane; water for 0.5h;99%
With water; sodium hydrogencarbonate In dichloromethane at 0℃; Product distribution / selectivity;96%
(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

formaldehyd
50-00-0

formaldehyd

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
at 40℃; for 4h; Darkness;98%
With hydrogenchloride In water at 20 - 80℃; for 2h;83.57%
Stage #1: (S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride; formaldehyd In water at 25 - 30℃; for 20 - 24h;
Stage #2: With sodium carbonate In dichloromethane; water at 12 - 15℃; for 0.75 - 3.25h; pH=7.01 - 7.32; Product distribution / selectivity;
C15H13ClO5S

C15H13ClO5S

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium carbonate In dichloromethane at 25 - 40℃; for 24h; Temperature;97.02%
SR 26334
144457-28-3

SR 26334

methanol
67-56-1

methanol

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
Stage #1: SR 26334 With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at -10 - 0℃; for 2.5h;
Stage #2: methanol In dichloromethane at 0 - 20℃; for 2.5h;
96%
Stage #1: SR 26334; methanol With acetyl chloride Heating / reflux;
Stage #2: With sodium hydroxide In water; ethyl acetate pH=7 - 8; Product distribution / selectivity;
91%
Stage #1: SR 26334; methanol With thionyl chloride at 70℃; for 6h;
Stage #2: With sodium hydrogencarbonate In water pH=7; Product distribution / selectivity;
88%
methanol
67-56-1

methanol

(S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride
144750-42-5

(S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
Stage #1: (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at -10 - 0℃; for 2.5h;
Stage #2: methanol In dichloromethane at 0 - 20℃; for 2.5h;
95%
Stage #1: methanol; (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride; sulfuric acid Heating / reflux;
Stage #2: With sodium hydroxide In water; ethyl acetate pH=8; Product distribution / selectivity;
Stage #1: methanol; (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride; sulfuric acid Heating / reflux;
Stage #2: With calcium hydroxide; sodium hydroxide In water pH=8; Product distribution / selectivity;
(+) clopidogrel (-) camphor sulfate

(+) clopidogrel (-) camphor sulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane pH=8; Conversion of starting material;95%
With potassium carbonate In dichloromethane; water pH=8; Conversion of starting material;
methanol
67-56-1

methanol

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile
444728-11-4

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide for 12h; Reflux;95%
clopidogrel besylate

clopidogrel besylate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water95%
methanol
67-56-1

methanol

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
Stage #1: (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride With dmap; triethylamine; methyl chloroformate In ethyl acetate at 20 - 30℃; for 1h;
Stage #2: methanol In ethyl acetate at 20℃; for 2h; Product distribution / selectivity;
92%
Stage #1: (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride With dmap; triethylamine; methyl chloroformate In dichloromethane at 20 - 30℃; for 1h;
Stage #2: methanol In dichloromethane at 20℃; for 2h; Product distribution / selectivity;
90%
Stage #1: SR 26334 With triethylamine; methyl chloroformate In dichloromethane at 20 - 30℃; for 1h;
Stage #2: methanol In dichloromethane at 20℃; for 2h; Product distribution / selectivity;
86%
Stage #1: C15H14ClNO2S*C19H22N2O With hydrogenchloride In water pH=4;
Stage #2: methanol With thionyl chloride In water at 70℃; for 6h;
Stage #3: With sodium hydrogencarbonate In water pH=7; Product distribution / selectivity;
60%
methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate
141109-20-8

methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate

formaldehyd
50-00-0

formaldehyd

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sulfuric acid In dichloromethane at 0 - 25℃;91.4%
Stage #1: methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate; formaldehyd In water at 60℃; for 0.333333 - 0.5h;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water pH=7 - 8; Product distribution / selectivity;
63%
Stage #1: methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate; formaldehyd With sodium hydrogencarbonate; potassium iodide In 1,2-dichloro-ethane for 4h; Reflux;
Stage #2: With hydrogenchloride In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 30℃; Reflux;
50%
SR 26334
144457-28-3

SR 26334

dimethyl sulfate
77-78-1

dimethyl sulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane; water at 0 - 20℃; for 12h; Product distribution / selectivity;89%
SR 26334
144457-28-3

SR 26334

methyl iodide
74-88-4

methyl iodide

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide for 5h; Product distribution / selectivity;88%
2-(2-bromoethyl)-3-(bromomethyl)thiophene
865187-82-2

2-(2-bromoethyl)-3-(bromomethyl)thiophene

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;88%
With N-ethyl-N,N-diisopropylamine In tert-butyl alcohol for 8.5h; Product distribution / selectivity; Heating / reflux;85%
With potassium carbonate In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;78%
With triethylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;41%
2-(2-chloroethyl)-3-chloromethylthiophene

2-(2-chloroethyl)-3-chloromethylthiophene

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;85%
6,7-dihydro-4H-thieno[3,2-c]pyran
865187-86-6

6,7-dihydro-4H-thieno[3,2-c]pyran

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyran With dibromotriphenylphosphorane In acetonitrile for 24h; Heating / reflux;
Stage #2: (S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;
81%
2-(3-hydroxymethylthiophen-2-yl)ethanol
865187-81-1

2-(3-hydroxymethylthiophen-2-yl)ethanol

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate
141109-14-0

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; Bis(p-nitrophenyl) phosphate In toluene at 100℃; for 36h; Solvent; Time; Temperature; Sealed tube; Molecular sieve; Green chemistry;80%
2-(thiophen-2-yl)ethyl methanesulfonate
61380-07-2

2-(thiophen-2-yl)ethyl methanesulfonate

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;79%
methanol
67-56-1

methanol

(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide
444728-13-6

(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

dimethyl sulfate
77-78-1

dimethyl sulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
Stage #1: methanol; dimethyl sulfate With sulfuric acid at 25 - 38℃; for 3h; Heating / reflux;
Stage #2: (+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide at 40 - 66℃; for 60h;
73%
(R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

(R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water for 2.5h; Reflux;70%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;58%
sodium (S)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-acetate
929250-04-4

sodium (S)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-acetate

dimethyl sulfate
77-78-1

dimethyl sulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With PEG400; sodium hydrogencarbonate In water; butan-1-ol at 10 - 40℃; for 31h; pH=~ 10; Product distribution / selectivity;51%
With sodium hydrogencarbonate; PEG 400 In water; butan-1-ol at 10 - 40℃; for 31h; pH=10; Product distribution / selectivity;51%
potassium (S)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-acetate
929250-05-5

potassium (S)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-acetate

dimethyl sulfate
77-78-1

dimethyl sulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With PEG400; sodium hydrogencarbonate In water; butan-1-ol at 10 - 40℃; for 31h; pH=~ 10; Product distribution / selectivity;51%
With sodium hydrogencarbonate; PEG 400 In water; butan-1-ol at 10 - 40℃; for 31h; pH=10; Product distribution / selectivity;51%
methyl 2-chloro-2-(2-chlorophenyl)acetate
90055-47-3

methyl 2-chloro-2-(2-chlorophenyl)acetate

4,5,6,7-tetrahydrothieno[3,2-c]pyridine
54903-50-3

4,5,6,7-tetrahydrothieno[3,2-c]pyridine

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 4h;45%
(S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride
144750-42-5

(S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride

methyl iodide
74-88-4

methyl iodide

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one Product distribution / selectivity;
methyl α-5(4,5,6,7-tetrahydro(3,2-c)thieno pyridyl) (2-chlorophenyl)-acetate isopropylsulfate

methyl α-5(4,5,6,7-tetrahydro(3,2-c)thieno pyridyl) (2-chlorophenyl)-acetate isopropylsulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; toluene Purification / work up;
5-sulfosalicylic Acid
97-05-2

5-sulfosalicylic Acid

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate 5-sulfosalicylate
1010080-15-5

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate 5-sulfosalicylate

Conditions
ConditionsYield
In methanol at 30℃; for 0.5h;100%
In dichloromethane at 20℃; for 0.5 - 1h; Product distribution / selectivity; Heating / reflux;100%
methanesulfonic acid
75-75-2

methanesulfonic acid

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

clopidogrel mesylate

clopidogrel mesylate

Conditions
ConditionsYield
In methanol at 5 - 35℃; for 12h;99.67%
In methanol for 36h; Heating / reflux;
In acetone for 2 - 10h; Heating / reflux;
In methanol for 2 - 10h; Heating / reflux;
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

(S)-(+)-clopidogrel bisulfate
120202-66-6

(S)-(+)-clopidogrel bisulfate

Conditions
ConditionsYield
With sulfuric acid In ethyl acetate at -5 - 30℃; for 3h; Temperature; Solvent;99%
With sulfuric acid In ethyl acetate at -5 - 30℃; for 3h; Temperature; Solvent; Concentration; Inert atmosphere;99%
With polyethylene glycol-200; sulfuric acid; sodium hydrogencarbonate In acetone at -5 - 20℃; for 0.0833333 - 0.116667h; pH=8; Conversion of starting material;96%
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

clopidogrel hydrobromide

clopidogrel hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In water; ethyl acetate at 10 - 15℃; for 1h; Product distribution / selectivity;98%
With hydrogen bromide In tetrahydrofuran; water at 20℃; Product distribution / selectivity;80%
With water; hydrogen bromide In dichloromethane; di-isopropyl ether; isopropyl alcohol at 20 - 27℃; for 3.66667h;80%
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

methyl (R)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate
120202-69-9

methyl (R)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate

clopidogrel
90055-48-4

clopidogrel

Conditions
ConditionsYield
With potassium carbonate In methanol for 3h; Product distribution / selectivity; Heating / reflux;96%
With sodium hydrogencarbonate In methanol for 3h; Product distribution / selectivity; Heating / reflux;94%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol for 3h; Product distribution / selectivity; Heating / reflux;92%
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

C16H13(2)H3ClNO2S

C16H13(2)H3ClNO2S

Conditions
ConditionsYield
With [(2)H6]acetone; tris(pentafluorophenyl)borate In toluene at 150℃; for 6h; Inert atmosphere;94%
benzenesulfonic acid
98-11-3

benzenesulfonic acid

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

clopidogrel besylate

clopidogrel besylate

Conditions
ConditionsYield
In water; acetone at 0 - 5℃; for 1h; Solvent; Time;92.6%
In acetone for 2 - 10h; Heating / reflux;
In n-heptane at 20℃;
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

C15H16ClNOS
1227294-01-0

C15H16ClNOS

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 20℃; for 20h;92%
(1S)-10-camphorsulfonic acid
3144-16-9

(1S)-10-camphorsulfonic acid

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

(+)-clopidogrel camphorsulfonic acid

(+)-clopidogrel camphorsulfonic acid

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 12h;91%
In ethyl acetate at 0 - 20℃; for 4h; Product distribution / selectivity;
In acetone at 0 - 5℃; for 2h; Product distribution / selectivity; methyl (+)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetic acid (1S)-(+)-camphor-10-sulfonate;
(1S)-(+)-10-camphorsulfonic acid

(1S)-(+)-10-camphorsulfonic acid

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

clopidogrel camphorsulfonate

clopidogrel camphorsulfonate

Conditions
ConditionsYield
In ethyl acetate at 0 - 20℃; for 5h; Product distribution / selectivity;90%
In di-isopropyl ether; acetone at 0 - 20℃; for 6h; Product distribution / selectivity;88%
In butanone at 0 - 20℃; for 4.5h; Product distribution / selectivity;86%
In 4-methyl-2-pentanone at 0 - 20℃; for 5h; Product distribution / selectivity;
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

(S)-clopidogrel hydrogen sulfate
1233025-55-2

(S)-clopidogrel hydrogen sulfate

Conditions
ConditionsYield
With sulfuric acid In 1,2-dimethoxyethane at 0 - 5℃; for 12h;90%
With sulfuric acid In ethanol; tert-butyl methyl ether at 0 - 5℃; for 10.5h;90%
With sulfuric acid In acetone82%
naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

clopidogrel 1,5-naphthalenedisulfonate

clopidogrel 1,5-naphthalenedisulfonate

Conditions
ConditionsYield
In water; acetone at 0 - 20℃; for 16.5h;90%
naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

methyl (+)-(S)-α-(o-chlorophenyl)-6,7-dihydrothieno[3,2-a]pyridine-5(4H)acetate 1,5-naphthalenedisulfonate monohydrate

methyl (+)-(S)-α-(o-chlorophenyl)-6,7-dihydrothieno[3,2-a]pyridine-5(4H)acetate 1,5-naphthalenedisulfonate monohydrate

Conditions
ConditionsYield
With water In acetone at 0 - 20℃; for 16.5h; Product distribution / selectivity;90%
In 1,4-dioxane; ethanol
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H)-acetate naphthalene-1,5-disulfonate

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H)-acetate naphthalene-1,5-disulfonate

Conditions
ConditionsYield
With naphthalene-1,5-disulfonate In water; acetone at 20℃; for 12.5h;90%
naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H)-acetate naphthalene-1,5-disulfonate

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H)-acetate naphthalene-1,5-disulfonate

Conditions
ConditionsYield
In water; acetone at 0 - 20℃; for 16.5h;90%
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