Product Name: Fluticasone propionate Synonyms: androsta-1,4-diene-17-carbothioicacid,6,9-difluoro-11-hydroxy-16-methyl-3-oxo;cci18781;fluticasone17-propionate;flutide;(6A,11B,16A,17A)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDRO
Cas:80474-14-2
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryAppearance:White or off-white powder Storage:Store in a cool, dry and well-ventilated area Package:10g/foil bag Application:Phrmaceutical intermediate Transportation:Prompt delivery Port:Shanghai port
Cas:80474-14-2
Min.Order:10 Gram
FOB Price: $37.0
Type:Trading Company
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:80474-14-2
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryUnique advantages for Fluticasone propionate Cas 80474-14-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white powder Storage:Store at RT Package:100g
Cas:80474-14-2
Min.Order:100 Gram
FOB Price: $11.0 / 15.0
Type:Trading Company
inquiryFluticasone propionate CAS No.:80474-14-2 Name: Fluticasone propionate Synonyms: S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate
Cas:80474-14-2
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:80474-14-2
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:80474-14-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryName:Fluticasone propionate The alias:Fluticasone propionate CAS NO:80474-14-2 EINECS NO:617-082-4 Molecular formula:C25H31F3O5S Molecular weight:500.57 Product Quality 12 years of chemical raw materials Mature operation of the industry
Cas:80474-14-2
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:80474-14-2
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu
Cas:80474-14-2
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:80474-14-2
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:80474-14-2
Min.Order:1 Kilogram
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Type:Trading Company
inquiryName Fluticasone propionate Synonyms S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate; (6a,11b,16a
Cas:80474-14-2
Min.Order:1 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiryAppearance:White powder Storage:room temperature Package:25kg/drum Application:Fluticasone Propionate is a derivative of Flumethasone, a glucocorticoid that has antiallergic, anti-asthmatic, and anti-inflammatory properties. It is used in the treat
Cas:80474-14-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:80474-14-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:80474-14-2
Min.Order:10 Gram
FOB Price: $1.3
Type:Trading Company
inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
Cas:80474-14-2
Min.Order:100 Kilogram
FOB Price: $1.0 / 5.0
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:80474-14-2
Min.Order:10 Gram
FOB Price: $35.0 / 50.0
Type:Trading Company
inquiryFluticasone propionate CAS:80474-14-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in
Cas:80474-14-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:80474-14-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAPI name: Flixotide,fluticasone propionate,CUTIVATE Certificates: In-house CAS No.: 80474-14-2 Chemical name: (6α, 11β, 16α, 17α) -6,9-diofluoro-11-hydroxyl-16-methyl-3-oxygen generation 17- (1-oxygen oxygen) male steroid -
Cas:80474-14-2
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiryProduct quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried
Cas:80474-14-2
Min.Order:1 Kilogram
FOB Price: $20.0 / 30.0
Type:Trading Company
inquiryOverview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie
Cas:80474-14-2
Min.Order:1 Kilogram
FOB Price: $150.0 / 180.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
Cas:80474-14-2
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:80474-14-2
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:80474-14-2
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryFluticasone propionate CAS 80474-14-2 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality c
Cas:80474-14-2
Min.Order:1 Kilogram
FOB Price: $10.0 / 50.0
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
S-hydroxymethyl 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate
flixotide
Conditions | Yield |
---|---|
With diethylamino-sulfur trifluoride In tetrahydrofuran at -20℃; for 0.333333h; | 68% |
With (bis-(2-methoxyethyl)amino)sulfur trufluoride In dichloromethane at -60℃; for 0.166667h; | 35% |
Conditions | Yield |
---|---|
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h; | 60% |
In acetonitrile at 5 - 50℃; under 760.051 - 975.098 Torr; for 22.5h; | 60% |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In N,N-dimethyl-formamide at -10 - 20℃; for 2h; | 91.7% |
With potassium carbonate In acetone at -5 - 0℃; for 2 - 5h; Product distribution / selectivity; | 84.51% |
Stage #1: 17-propionate carbothioic acid With potassium carbonate In acetone at 20℃; for 0.5h; Stage #2: bromofluoromethane In acetone at 0 - 5℃; | 80% |
S-iodomethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxo-androsta-1,4-diene-17β-carbothioate
flixotide
Conditions | Yield |
---|---|
With calcium fluoride; silver fluoride In acetonitrile at -15 - -10℃; for 48h; | 75% |
With silver fluoride In acetonitrile for 4h; Ambient temperature; | 74% |
With calcium fluoride; silver fluoride In acetonitrile at -15 - -10℃; for 48h; Product distribution / selectivity; | 60% |
With silver fluoride In acetonitrile at 0 - 5℃; for 75h; Product distribution / selectivity; | 40% |
Multi-step reaction with 2 steps 1: 74.2 percent / acetonitrile / 1.17 h / 20 °C 2: 43 percent Spectr. / KF, KI, aminopolyether 2.2.2 / acetonitrile / 0.58 h / 100 °C / 1050.08 Torr View Scheme |
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 20℃; for 6h; chemoselective reaction; | 82% |
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 22 - 25℃; for 0.25h; | 67.1% |
With potassium carbonate; sodium hydrogensulfite In acetone at -10℃; |
C27H30F6O6S
flixotide
Conditions | Yield |
---|---|
With methanol; ammonia at 0℃; for 0.0833333h; | |
With ammonia In methanol at 0℃; for 0.0833333h; | 0.041 g |
S-fluoromethyl 6α-fluoro-9β,11β-epoxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate
flixotide
Conditions | Yield |
---|---|
With hydrogen fluoride In water at -20℃; for 7h; |
Conditions | Yield |
---|---|
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h; |
Conditions | Yield |
---|---|
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h; |
Conditions | Yield |
---|---|
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h; |
Conditions | Yield |
---|---|
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h; |
Conditions | Yield |
---|---|
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h; |
Conditions | Yield |
---|---|
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h; |
P-(monofluoromethyl)triphenylphosphonium tetrafluoroborate
17-propionate carbothioic acid
flixotide
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 20℃; |
N-(monofluoromethyl)-N-phenyl-dimethylammonium triflate
17-propionate carbothioic acid
flixotide
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 20℃; |
17-propionate carbothioic acid
flixotide
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 20℃; |
R32
N-ethyl-N,N-diisopropylamine
17-propionate carbothioic acid
flixotide
Conditions | Yield |
---|---|
Stage #1: N-ethyl-N,N-diisopropylamine; 17-propionate carbothioic acid In acetonitrile for 0.25h; Stage #2: Stage #3: R32 In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h; |
Conditions | Yield |
---|---|
base; | |
With potassium thiosulfate; 2-methylacrylic acid 3-hydroxypropyl ester at 10℃; |
6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate
flixotide
Conditions | Yield |
---|---|
With 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octanebis(tetrafluoroborate); silver nitrate In water; acetone at 45℃; for 3h; Temperature; Solvent; Time; Inert atmosphere; Green chemistry; | 83% |
17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene
flixotide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et2NH / Heating 2: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: Et2NH / Heating 2: 9.4 percent / K2CO3 / dimethylformamide / 1 h / -5 - 0 °C View Scheme | |
Multi-step reaction with 4 steps 1: Et2NH / Heating 2: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h 3: 85 percent / NaI / acetone / Heating 4: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature View Scheme |
6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylic acid
flixotide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 20 °C 2: Et2NH / Heating 3: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 20 °C 2: Et2NH / Heating 3: 9.4 percent / K2CO3 / dimethylformamide / 1 h / -5 - 0 °C View Scheme | |
Multi-step reaction with 5 steps 1: Et3N / CH2Cl2 / 20 °C 2: Et2NH / Heating 3: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h 4: 85 percent / NaI / acetone / Heating 5: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium iodide; triethylamine / tetrahydrofuran / 4 h / 70 - 75 °C 2.1: morpholine / 3 h / 20 °C 3.1: potassium carbonate / acetone / 0.5 h / 20 °C 3.2: 0 - 5 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine; sodium iodide / acetone; water / 6 h / 10 - 30 °C 1.2: 1 h / 0 °C 2.1: potassium carbonate / methanol / 5 h / 25 °C / Inert atmosphere 3.1: triethylamine / acetone / 5 h / 25 °C 3.2: 0 °C / pH 1 - 1.5 4.1: silver nitrate; 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octanebis(tetrafluoroborate) / acetone; water / 3 h / 45 °C / Inert atmosphere; Green chemistry View Scheme |
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid
flixotide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: dimethylformamide / 4 h / Ambient temperature 2: H2S / dimethylformamide 3: Et3N / CH2Cl2 / 0.75 h 4: Et2NH / acetone / 1 h 5: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C View Scheme | |
Multi-step reaction with 5 steps 1: dimethylformamide / 4 h / Ambient temperature 2: H2S / dimethylformamide 3: Et3N / CH2Cl2 / 0.75 h 4: Et2NH / acetone / 1 h 5: 9.4 percent / K2CO3 / dimethylformamide / 1 h / -5 - 0 °C View Scheme | |
Multi-step reaction with 7 steps 1: dimethylformamide / 4 h / Ambient temperature 2: H2S / dimethylformamide 3: Et3N / CH2Cl2 / 0.75 h 4: Et2NH / acetone / 1 h 5: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h 6: 85 percent / NaI / acetone / Heating 7: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine / acetone / 3 h / 0 - 5 °C 1.2: 2.5 h / 40 - 45 °C 2.1: sodium iodide; triethylamine / tetrahydrofuran / 4 h / 70 - 75 °C 3.1: morpholine / 3 h / 20 °C 4.1: potassium carbonate / acetone / 0.5 h / 20 °C 4.2: 0 - 5 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / acetone / 4 h / 10 - 25 °C 1.2: 10 - 25 °C 1.3: 0 °C / pH 1 - 1.5 2.1: triethylamine; sodium iodide / acetone; water / 6 h / 10 - 30 °C 2.2: 1 h / 0 °C 3.1: potassium carbonate / methanol / 5 h / 25 °C / Inert atmosphere 4.1: triethylamine / acetone / 5 h / 25 °C 4.2: 0 °C / pH 1 - 1.5 5.1: silver nitrate; 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octanebis(tetrafluoroborate) / acetone; water / 3 h / 45 °C / Inert atmosphere; Green chemistry View Scheme |
17-propionate carbothioic acid
flixotide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h 2: 85 percent / NaI / acetone / Heating 3: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature View Scheme | |
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 3 h / 20 °C 2: triethylamine / dmap / tetrahydrofuran / 20 °C 3: trifluoroacetic acid / 2 h / 20 °C 4: xenon fluoride / dichloromethane / 48 h / -10 °C 5: ammonia; methanol / 0.08 h / 0 °C View Scheme | |
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 3 h / 20 °C 2: triethylamine; dmap / tetrahydrofuran / 20 °C 3: trifluoroacetic acid / 2 h / 20 °C 4: xenon difluoride / dichloromethane / 48 h / -10 °C 5: ammonia / methanol / 0.08 h / 0 °C View Scheme |
bromofluoromethane
17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene
flixotide
Conditions | Yield |
---|---|
Stage #1: 17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene With sodium hydrogensulfide In ISOPROPYLAMIDE at 0 - 20℃; for 4h; Stage #2: bromofluoromethane In ISOPROPYLAMIDE at -5℃; for 1h; Stage #3: With dihydrogen peroxide In ISOPROPYLAMIDE; water at 20℃; for 0.5h; Product distribution / selectivity; | |
Stage #1: 17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene With methanol; potassium carbonate at 20℃; for 5.5h; Stage #2: bromofluoromethane at -5 - 0℃; for 7.5h; Product distribution / selectivity; |
Propionic acid (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(toluene-4-sulfonyloxymethylsulfanylcarbonyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester
A
flixotide
B
S-iodomethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxo-androsta-1,4-diene-17β-carbothioate
Conditions | Yield |
---|---|
With potassium fluoride; aminopolyether 2.2.2; potassium iodide In acetonitrile at 100℃; under 1050.08 Torr; for 0.583333h; | A 43 % Spectr. B 21 % Spectr. C 24 % Spectr. |
17-propionate carbothioic acid
flixotide
Conditions | Yield |
---|---|
With caesium carbonate In dichloromethane at 20℃; Product distribution / selectivity; |
17-propionate carbothioic acid
flixotide
Conditions | Yield |
---|---|
With caesium carbonate In dichloromethane at 20℃; Product distribution / selectivity; |
S-chloromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate
flixotide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 90.1 percent / NaI / acetone / 2 h / Heating 2: 74.2 percent / acetonitrile / 1.17 h / 20 °C 3: 43 percent Spectr. / KF, KI, aminopolyether 2.2.2 / acetonitrile / 0.58 h / 100 °C / 1050.08 Torr View Scheme | |
Multi-step reaction with 2 steps 1: 85 percent / NaI / acetone / Heating 2: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature View Scheme |
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid
flixotide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 0.75 h 2: Et2NH / acetone / 1 h 3: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 0.75 h 2: Et2NH / acetone / 1 h 3: 9.4 percent / K2CO3 / dimethylformamide / 1 h / -5 - 0 °C View Scheme | |
Multi-step reaction with 5 steps 1: Et3N / CH2Cl2 / 0.75 h 2: Et2NH / acetone / 1 h 3: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h 4: 85 percent / NaI / acetone / Heating 5: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature View Scheme |
flixotide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: H2S / dimethylformamide 2: Et3N / CH2Cl2 / 0.75 h 3: Et2NH / acetone / 1 h 4: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C View Scheme | |
Multi-step reaction with 4 steps 1: H2S / dimethylformamide 2: Et3N / CH2Cl2 / 0.75 h 3: Et2NH / acetone / 1 h 4: 9.4 percent / K2CO3 / dimethylformamide / 1 h / -5 - 0 °C View Scheme | |
Multi-step reaction with 6 steps 1: H2S / dimethylformamide 2: Et3N / CH2Cl2 / 0.75 h 3: Et2NH / acetone / 1 h 4: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h 5: 85 percent / NaI / acetone / Heating 6: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature View Scheme |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 168h; Cooling with ice; | 99% |
flixotide
Conditions | Yield |
---|---|
With triethylamine; phosphorus trichloride In tetrahydrofuran at -78 - 20℃; for 26h; | 94% |
Elaidic acid
flixotide
Fluticasone propionate 11beta-elaidic acid ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 164h; | 79% |
2-(triphenylmethylthio)ethanoic acid
flixotide
Conditions | Yield |
---|---|
With dmap In dichloromethane at 20℃; | 71% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; | 63% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 168h; Cooling with ice; | 63% |
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