Products

Refine

Country

Business Type

Certificate

Display

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Fluticasone propionate Synonyms: androsta-1,4-diene-17-carbothioicacid,6,9-difluoro-11-hydroxy-16-methyl-3-oxo;cci18781;fluticasone17-propionate;flutide;(6A,11B,16A,17A)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDRO

Fluticasone propionate 99% Manufactuered in China best quality

Cas:80474-14-2

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Wuhan PharmChem Co.,Ltd

Appearance:White or off-white powder Storage:Store in a cool, dry and well-ventilated area Package:10g/foil bag Application:Phrmaceutical intermediate Transportation:Prompt delivery Port:Shanghai port

99% Fluticasone propionate C25H31F3O5S

Cas:80474-14-2

Min.Order:10 Gram

FOB Price: $37.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Fluticasone Propionate CAS NO.80474-14-2

Cas:80474-14-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Fluticasone propionate Cas 80474-14-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white powder Storage:Store at RT Package:100g

Factory supply Fluticasone propionate Cas 80474-14-2 with high quality and best price

Cas:80474-14-2

Min.Order:100 Gram

FOB Price: $11.0 / 15.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Fluticasone propionate CAS No.:80474-14-2 Name: Fluticasone propionate Synonyms: S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate

High purity Fluticasone propionate CAS No.:80474-14-2

Cas:80474-14-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Fluticasone Propionate

Cas:80474-14-2

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Fluticasone propionate 80474-14-2 GMP Manufacturer

Cas:80474-14-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Fluticasone propionate

Cas:80474-14-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Fluticasone propionate The alias:Fluticasone propionate CAS NO:80474-14-2 EINECS NO:617-082-4 Molecular formula:C25H31F3O5S Molecular weight:500.57 Product Quality 12 years of chemical raw materials Mature operation of the industry

Fluticasone propionate/CAS:80474-14-2/High quality

Cas:80474-14-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

top Fluticasone propionate

Cas:80474-14-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu

Fluticasone propionate

Cas:80474-14-2

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

HRK-Fluticasone propionate: 80474-14-2

Cas:80474-14-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 80474-14-2 with best quality

Cas:80474-14-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name Fluticasone propionate Synonyms S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate; (6a,11b,16a

Fluticasone propionate

Cas:80474-14-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:room temperature Package:25kg/drum Application:Fluticasone Propionate is a derivative of Flumethasone, a glucocorticoid that has antiallergic, anti-asthmatic, and anti-inflammatory properties. It is used in the treat

Fluticasone propionate factory price

Cas:80474-14-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Fluticasone propionate 80474-14-2

Cas:80474-14-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Fluticasone propionate CAS 80474-14-2

Cas:80474-14-2

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Fluticasone propionate

Cas:80474-14-2

Min.Order:10 Gram

FOB Price: $35.0 / 50.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Fluticasone propionate CAS:80474-14-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

Fluticasone propionate CAS:80474-14-2

Cas:80474-14-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Fluticasone propionate

Cas:80474-14-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

API name: Flixotide,fluticasone propionate,CUTIVATE Certificates: In-house CAS No.: 80474-14-2 Chemical name: (6α, 11β, 16α, 17α) -6,9-diofluoro-11-hydroxyl-16-methyl-3-oxygen generation 17- (1-oxygen oxygen) male steroid -

Flixotide,fluticasone propionate,CUTIVATE

Cas:80474-14-2

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

Fluticasone propionate CAS NO.80474-14-2

Cas:80474-14-2

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Leader Biochemical Group

Overview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie

China Biggest Factory & Manufacturer supply Fluticasone propionate 100MT/Year

Cas:80474-14-2

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Fluticasone propionate

Cas:80474-14-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Fluticasone propionate 80474-14-2

Cas:80474-14-2

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Fluticasone Propionate

Cas:80474-14-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Fluticasone Propionate CAS NO.80474-14-2

Cas:80474-14-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hefei Zhaobo Technology Co., Ltd.

Fluticasone propionate CAS 80474-14-2 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality c

Fluticasone propionate CAS 80474-14-2

Cas:80474-14-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Fluticasone Propionate

Cas:80474-14-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

S-hydroxymethyl 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate
709002-83-5

S-hydroxymethyl 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With diethylamino-sulfur trifluoride In tetrahydrofuran at -20℃; for 0.333333h;68%
With (bis-(2-methoxyethyl)amino)sulfur trufluoride In dichloromethane at -60℃; for 0.166667h;35%
6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methylpregna-3-oxo-1,4-diene-17β-thiocarboxylic acid diisopropylethylamine salt

6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methylpregna-3-oxo-1,4-diene-17β-thiocarboxylic acid diisopropylethylamine salt

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h;60%
In acetonitrile at 5 - 50℃; under 760.051 - 975.098 Torr; for 22.5h;60%
bromofluoromethane
373-52-4

bromofluoromethane

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at -10 - 20℃; for 2h;91.7%
With potassium carbonate In acetone at -5 - 0℃; for 2 - 5h; Product distribution / selectivity;84.51%
Stage #1: 17-propionate carbothioic acid With potassium carbonate In acetone at 20℃; for 0.5h;
Stage #2: bromofluoromethane In acetone at 0 - 5℃;
80%
S-iodomethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxo-androsta-1,4-diene-17β-carbothioate
80474-67-5

S-iodomethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxo-androsta-1,4-diene-17β-carbothioate

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With calcium fluoride; silver fluoride In acetonitrile at -15 - -10℃; for 48h;75%
With silver fluoride In acetonitrile for 4h; Ambient temperature;74%
With calcium fluoride; silver fluoride In acetonitrile at -15 - -10℃; for 48h; Product distribution / selectivity;60%
With silver fluoride In acetonitrile at 0 - 5℃; for 75h; Product distribution / selectivity;40%
Multi-step reaction with 2 steps
1: 74.2 percent / acetonitrile / 1.17 h / 20 °C
2: 43 percent Spectr. / KF, KI, aminopolyether 2.2.2 / acetonitrile / 0.58 h / 100 °C / 1050.08 Torr
View Scheme
fluoroiodomethane
373-53-5

fluoroiodomethane

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃; for 6h; chemoselective reaction;82%
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 22 - 25℃; for 0.25h;67.1%
With potassium carbonate; sodium hydrogensulfite In acetone at -10℃;
C27H30F6O6S
1414857-56-9

C27H30F6O6S

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With methanol; ammonia at 0℃; for 0.0833333h;
With ammonia In methanol at 0℃; for 0.0833333h;0.041 g
S-fluoromethyl 6α-fluoro-9β,11β-epoxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate
192191-49-4

S-fluoromethyl 6α-fluoro-9β,11β-epoxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With hydrogen fluoride In water at -20℃; for 7h;
6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methyl-pregna-3-oxo-1,4-diene-17β-thiocarboxylic acid triethylamine salt

6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methyl-pregna-3-oxo-1,4-diene-17β-thiocarboxylic acid triethylamine salt

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h;
6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methyl-pregna-3-oxo-1,4-diene-17β-thiocarboxylic acid N-methylpiperidine salt

6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methyl-pregna-3-oxo-1,4-diene-17β-thiocarboxylic acid N-methylpiperidine salt

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h;
diethylammonium 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy;-17α-propionyloxyandrosta-1,4-diene-17β-thiocarboxylate

diethylammonium 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy;-17α-propionyloxyandrosta-1,4-diene-17β-thiocarboxylate

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h;
C4H9NO*C24H30F2O5S

C4H9NO*C24H30F2O5S

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h;
C12H23N*C24H30F2O5S

C12H23N*C24H30F2O5S

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h;
C6H13N*C24H30F2O5S

C6H13N*C24H30F2O5S

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h;
P-(monofluoromethyl)triphenylphosphonium tetrafluoroborate
96385-23-8

P-(monofluoromethyl)triphenylphosphonium tetrafluoroborate

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃;
N-(monofluoromethyl)-N-phenyl-dimethylammonium triflate
1351445-70-9

N-(monofluoromethyl)-N-phenyl-dimethylammonium triflate

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃;
N-(monofluoromethyl)-N-phenyldimethylammonium tetrafluoroborate

N-(monofluoromethyl)-N-phenyldimethylammonium tetrafluoroborate

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃;
N-ethyl-N,N-diisopropylamine
7087-68-5

N-ethyl-N,N-diisopropylamine

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
Stage #1: N-ethyl-N,N-diisopropylamine; 17-propionate carbothioic acid In acetonitrile for 0.25h;
Stage #2:
Stage #3: R32 In acetonitrile at 5 - 50℃; under 975.098 Torr; for 22.5h;
17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
base;
With potassium thiosulfate; 2-methylacrylic acid 3-hydroxypropyl ester at 10℃;
6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate
1351451-82-5

6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octanebis(tetrafluoroborate); silver nitrate In water; acetone at 45℃; for 3h; Temperature; Solvent; Time; Inert atmosphere; Green chemistry;83%
17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene
105638-31-1

17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et2NH / Heating
2: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: Et2NH / Heating
2: 9.4 percent / K2CO3 / dimethylformamide / 1 h / -5 - 0 °C
View Scheme
Multi-step reaction with 4 steps
1: Et2NH / Heating
2: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h
3: 85 percent / NaI / acetone / Heating
4: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature
View Scheme
6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylic acid
65429-42-7

6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2 / 20 °C
2: Et2NH / Heating
3: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2 / 20 °C
2: Et2NH / Heating
3: 9.4 percent / K2CO3 / dimethylformamide / 1 h / -5 - 0 °C
View Scheme
Multi-step reaction with 5 steps
1: Et3N / CH2Cl2 / 20 °C
2: Et2NH / Heating
3: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h
4: 85 percent / NaI / acetone / Heating
5: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1.1: sodium iodide; triethylamine / tetrahydrofuran / 4 h / 70 - 75 °C
2.1: morpholine / 3 h / 20 °C
3.1: potassium carbonate / acetone / 0.5 h / 20 °C
3.2: 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine; sodium iodide / acetone; water / 6 h / 10 - 30 °C
1.2: 1 h / 0 °C
2.1: potassium carbonate / methanol / 5 h / 25 °C / Inert atmosphere
3.1: triethylamine / acetone / 5 h / 25 °C
3.2: 0 °C / pH 1 - 1.5
4.1: silver nitrate; 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octanebis(tetrafluoroborate) / acetone; water / 3 h / 45 °C / Inert atmosphere; Green chemistry
View Scheme
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid
28416-82-2

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: dimethylformamide / 4 h / Ambient temperature
2: H2S / dimethylformamide
3: Et3N / CH2Cl2 / 0.75 h
4: Et2NH / acetone / 1 h
5: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C
View Scheme
Multi-step reaction with 5 steps
1: dimethylformamide / 4 h / Ambient temperature
2: H2S / dimethylformamide
3: Et3N / CH2Cl2 / 0.75 h
4: Et2NH / acetone / 1 h
5: 9.4 percent / K2CO3 / dimethylformamide / 1 h / -5 - 0 °C
View Scheme
Multi-step reaction with 7 steps
1: dimethylformamide / 4 h / Ambient temperature
2: H2S / dimethylformamide
3: Et3N / CH2Cl2 / 0.75 h
4: Et2NH / acetone / 1 h
5: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h
6: 85 percent / NaI / acetone / Heating
7: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / acetone / 3 h / 0 - 5 °C
1.2: 2.5 h / 40 - 45 °C
2.1: sodium iodide; triethylamine / tetrahydrofuran / 4 h / 70 - 75 °C
3.1: morpholine / 3 h / 20 °C
4.1: potassium carbonate / acetone / 0.5 h / 20 °C
4.2: 0 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / acetone / 4 h / 10 - 25 °C
1.2: 10 - 25 °C
1.3: 0 °C / pH 1 - 1.5
2.1: triethylamine; sodium iodide / acetone; water / 6 h / 10 - 30 °C
2.2: 1 h / 0 °C
3.1: potassium carbonate / methanol / 5 h / 25 °C / Inert atmosphere
4.1: triethylamine / acetone / 5 h / 25 °C
4.2: 0 °C / pH 1 - 1.5
5.1: silver nitrate; 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octanebis(tetrafluoroborate) / acetone; water / 3 h / 45 °C / Inert atmosphere; Green chemistry
View Scheme
17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h
2: 85 percent / NaI / acetone / Heating
3: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 3 h / 20 °C
2: triethylamine / dmap / tetrahydrofuran / 20 °C
3: trifluoroacetic acid / 2 h / 20 °C
4: xenon fluoride / dichloromethane / 48 h / -10 °C
5: ammonia; methanol / 0.08 h / 0 °C
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 3 h / 20 °C
2: triethylamine; dmap / tetrahydrofuran / 20 °C
3: trifluoroacetic acid / 2 h / 20 °C
4: xenon difluoride / dichloromethane / 48 h / -10 °C
5: ammonia / methanol / 0.08 h / 0 °C
View Scheme
bromofluoromethane
373-52-4

bromofluoromethane

17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene
105638-31-1

17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
Stage #1: 17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene With sodium hydrogensulfide In ISOPROPYLAMIDE at 0 - 20℃; for 4h;
Stage #2: bromofluoromethane In ISOPROPYLAMIDE at -5℃; for 1h;
Stage #3: With dihydrogen peroxide In ISOPROPYLAMIDE; water at 20℃; for 0.5h; Product distribution / selectivity;
Stage #1: 17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene With methanol; potassium carbonate at 20℃; for 5.5h;
Stage #2: bromofluoromethane at -5 - 0℃; for 7.5h; Product distribution / selectivity;
Propionic acid (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(toluene-4-sulfonyloxymethylsulfanylcarbonyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester
192191-50-7

Propionic acid (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(toluene-4-sulfonyloxymethylsulfanylcarbonyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester

A

flixotide
80474-14-2

flixotide

B

S-iodomethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxo-androsta-1,4-diene-17β-carbothioate
80474-67-5

S-iodomethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxo-androsta-1,4-diene-17β-carbothioate

C

C49H60F4O10S2

C49H60F4O10S2

Conditions
ConditionsYield
With potassium fluoride; aminopolyether 2.2.2; potassium iodide In acetonitrile at 100℃; under 1050.08 Torr; for 0.583333h;A 43 % Spectr.
B 21 % Spectr.
C 24 % Spectr.
S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulphonium tetrafluoroborate

S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulphonium tetrafluoroborate

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With caesium carbonate In dichloromethane at 20℃; Product distribution / selectivity;
S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium triflate

S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium triflate

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With caesium carbonate In dichloromethane at 20℃; Product distribution / selectivity;
S-chloromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate
80486-69-7

S-chloromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90.1 percent / NaI / acetone / 2 h / Heating
2: 74.2 percent / acetonitrile / 1.17 h / 20 °C
3: 43 percent Spectr. / KF, KI, aminopolyether 2.2.2 / acetonitrile / 0.58 h / 100 °C / 1050.08 Torr
View Scheme
Multi-step reaction with 2 steps
1: 85 percent / NaI / acetone / Heating
2: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature
View Scheme
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid
80473-92-3

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2 / 0.75 h
2: Et2NH / acetone / 1 h
3: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2 / 0.75 h
2: Et2NH / acetone / 1 h
3: 9.4 percent / K2CO3 / dimethylformamide / 1 h / -5 - 0 °C
View Scheme
Multi-step reaction with 5 steps
1: Et3N / CH2Cl2 / 0.75 h
2: Et2NH / acetone / 1 h
3: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h
4: 85 percent / NaI / acetone / Heating
5: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature
View Scheme
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(imidazole-1-carbonyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(imidazole-1-carbonyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2S / dimethylformamide
2: Et3N / CH2Cl2 / 0.75 h
3: Et2NH / acetone / 1 h
4: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1: H2S / dimethylformamide
2: Et3N / CH2Cl2 / 0.75 h
3: Et2NH / acetone / 1 h
4: 9.4 percent / K2CO3 / dimethylformamide / 1 h / -5 - 0 °C
View Scheme
Multi-step reaction with 6 steps
1: H2S / dimethylformamide
2: Et3N / CH2Cl2 / 0.75 h
3: Et2NH / acetone / 1 h
4: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h
5: 85 percent / NaI / acetone / Heating
6: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature
View Scheme
3-(tert-butyloxycarbonylamino)propionic acid
3303-84-2

3-(tert-butyloxycarbonylamino)propionic acid

flixotide
80474-14-2

flixotide

C33H44F3NO8S

C33H44F3NO8S

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 168h; Cooling with ice;99%
flixotide
80474-14-2

flixotide

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-11-((hydroxyhydrophosphoryl)oxy)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-11-((hydroxyhydrophosphoryl)oxy)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

Conditions
ConditionsYield
With triethylamine; phosphorus trichloride In tetrahydrofuran at -78 - 20℃; for 26h;94%
Elaidic acid
112-79-8

Elaidic acid

flixotide
80474-14-2

flixotide

Fluticasone propionate 11beta-elaidic acid ester
1059627-22-3

Fluticasone propionate 11beta-elaidic acid ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 164h;79%
2-(triphenylmethylthio)ethanoic acid
34914-36-8

2-(triphenylmethylthio)ethanoic acid

flixotide
80474-14-2

flixotide

11-O-[2-(tritylmercapto)acetyl]fluticasone propionate

11-O-[2-(tritylmercapto)acetyl]fluticasone propionate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃;71%
BOC-glycine
4530-20-5

BOC-glycine

flixotide
80474-14-2

flixotide

C32H42F3NO8S

C32H42F3NO8S

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;63%
3-[(tert-butoxycarbonyl)amino]-2-fluoropropanoic acid

3-[(tert-butoxycarbonyl)amino]-2-fluoropropanoic acid

flixotide
80474-14-2

flixotide

C33H43F4NO8S

C33H43F4NO8S

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 168h; Cooling with ice;63%
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View