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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

FLUTICASONE PROPIONATE INTERMEDIATE

Cas:80474-45-9

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

FLUTICASONE PROPIONATE INTERMEDIATE

Cas:80474-45-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 80474-45-9 with competitive price

Cas:80474-45-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Qingdao Beluga Import and Export Co., LTD

FLUTICASONE PROPIONATE INTERMEDIATE CAS:80474-45-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

FLUTICASONE PROPIONATE INTERMEDIATE CAS:80474-45-9

Cas:80474-45-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

FLUTICASONE PROPIONATE INTERMEDIATE

Cas:80474-45-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Henan Tianfu Chemical Co., Ltd.

PackingGroup II Appearance:white powder Storage:room temperature Package:200KG Application:Industrial Grade Transportation:By sea , by air or express Port:China main port

TIANFU-CHEM FLUTICASONE PROPIONATE INTERMEDIATE

Cas:80474-45-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

FLUTICASONEPROPIONATEINTERMEDIATE

Cas:80474-45-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

FLUTICASONE PROPIONATE INTERMEDIATE

Cas:80474-45-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Luyunjia Chemistry Xiamen Limited

Luyunjia Chemistry Xiamen Limited is a high-tech company specializing in R&D and manufacturing of photoinitiators monomers and oligomers, UV absorbers and pharmaceutical intermediates, and pharmaceutical intermediates of generic drug. and has a h

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

FLUTICASONE PROPIONATE INTERMEDIATE

Cas:80474-45-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-m...

Cas:80474-45-9

Min.Order:0

Negotiable

Type:Other

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

FLUTICASONE PROPIONATE INTERMEDIATE

Cas:80474-45-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

FLUTICASONE PROPIONATE INTERMEDIATE

Cas:80474-45-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

FLUTICASONE PROPIONATE INTERMEDIATE

Cas:80474-45-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

F(n-1)

Cas:80474-45-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

Synthetic route

17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene
105638-31-1

17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
Stage #1: 17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene With methanol; potassium carbonate at 20℃; for 5 - 7h;
Stage #2: With hydrogenchloride In water at 20℃; pH=1.5 - 2.0; Product distribution / selectivity;
96.33%
With calcium hydroxide In methanol at 25 - 30℃; for 24h; Reagent/catalyst;96.3%
With potassium carbonate In methanol at 25℃; for 5h; Inert atmosphere;95%
propionyl chloride
79-03-8

propionyl chloride

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid
80473-92-3

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
Stage #1: propionyl chloride; 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid With triethylamine In dichloromethane at -5℃;
Stage #2: With diethylamine In acetone for 1h; regioselective reaction;
91%
With pyridine In acetone at -20 - -15℃; Product distribution / selectivity;88%
With 1-methyl-1H-imidazole In acetone at -20 - -15℃; Product distribution / selectivity;88%
6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylic acid
65429-42-7

6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylic acid

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
Stage #1: 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylic acid With 1-methyl-1H-imidazole In ISOPROPYLAMIDE at 50℃;
Stage #2: With sodium hydrogensulfide In ISOPROPYLAMIDE at 35℃; for 0.25h;
Stage #3: With hydrogenchloride In ISOPROPYLAMIDE; water pH=2;
32%
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 20 °C
2: Et2NH / Heating
View Scheme
Multi-step reaction with 2 steps
1: sodium iodide; triethylamine / tetrahydrofuran / 4 h / 70 - 75 °C
2: morpholine / 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: triethylamine; sodium iodide / acetone; water / 6 h / 10 - 30 °C
1.2: 1 h / 0 °C
2.1: potassium carbonate / methanol / 5 h / 25 °C / Inert atmosphere
View Scheme
Propionic acid (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propionylsulfanylcarbonyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester
577965-09-4

Propionic acid (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propionylsulfanylcarbonyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
With diethylamine In acetone for 1h; Yield given;
C24H29F2O5S(1-)*K(1+)
578740-28-0

C24H29F2O5S(1-)*K(1+)

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
With hydrogenchloride; water In methanol at 20℃; pH=1 - 2;
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid
80473-92-3

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 0.75 h
2: Et2NH / acetone / 1 h
View Scheme
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid
28416-82-2

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dimethylformamide / 4 h / Ambient temperature
2: H2S / dimethylformamide
3: Et3N / CH2Cl2 / 0.75 h
4: Et2NH / acetone / 1 h
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / acetone / 3 h / 0 - 5 °C
1.2: 2.5 h / 40 - 45 °C
2.1: sodium iodide; triethylamine / tetrahydrofuran / 4 h / 70 - 75 °C
3.1: morpholine / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / acetone / 4 h / 10 - 25 °C
1.2: 10 - 25 °C
1.3: 0 °C / pH 1 - 1.5
2.1: triethylamine; sodium iodide / acetone; water / 6 h / 10 - 30 °C
2.2: 1 h / 0 °C
3.1: potassium carbonate / methanol / 5 h / 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / acetone / 1 h / 0 - 10 °C
1.2: 2 h
2.1: sodium iodide; triethylamine / tetrahydrofuran / 16 h / 20 °C
3.1: calcium hydroxide / methanol / 24 h / 25 - 30 °C
View Scheme
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(imidazole-1-carbonyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(imidazole-1-carbonyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2S / dimethylformamide
2: Et3N / CH2Cl2 / 0.75 h
3: Et2NH / acetone / 1 h
View Scheme
C28H33F2NO8

C28H33F2NO8

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
With sodium hydrogensulfide In ISOPROPYLAMIDE at 35℃; for 0.25h;
17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene
105638-31-1

17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene

A

methyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carboxylate
59860-80-9

methyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carboxylate

B

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
With methanol; potassium carbonate at 20℃; for 1 - 5h; Product distribution / selectivity;
With methanol; caesium carbonate at 20℃; for 1 - 5h; Product distribution / selectivity;
propionyl chloride
79-03-8

propionyl chloride

diethylamine
109-89-7

diethylamine

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid
80473-92-3

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane; ethyl acetate; acetone
propanethioic acid
1892-31-5

propanethioic acid

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid
28416-82-2

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
Stage #1: 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 5℃; for 18h; Inert atmosphere;
Stage #2: propanethioic acid In tetrahydrofuran at 5 - 25℃; for 7h; Product distribution / selectivity; Inert atmosphere;
flumetasone
2135-17-3

flumetasone

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium periodate / water; tetrahydrofuran / 2 h / 25 - 30 °C
2.1: triethylamine / acetone / 3 h / 0 - 5 °C
2.2: 2.5 h / 40 - 45 °C
3.1: sodium iodide; triethylamine / tetrahydrofuran / 4 h / 70 - 75 °C
4.1: morpholine / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: periodic acid / water; tetrahydrofuran / 2 h / 0 - 10 °C
2.1: triethylamine / acetone / 1 h / 0 - 10 °C
2.2: 2 h
3.1: sodium iodide; triethylamine / tetrahydrofuran / 16 h / 20 °C
4.1: calcium hydroxide / methanol / 24 h / 25 - 30 °C
View Scheme
6α,9α-difluoro-11β, 17α-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione

6α,9α-difluoro-11β, 17α-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hypobromide / 1,4-dioxane / 5 h / 8 °C
2.1: triethylamine / acetone / 4 h / 10 - 25 °C
2.2: 10 - 25 °C
2.3: 0 °C / pH 1 - 1.5
3.1: triethylamine; sodium iodide / acetone; water / 6 h / 10 - 30 °C
3.2: 1 h / 0 °C
4.1: potassium carbonate / methanol / 5 h / 25 °C / Inert atmosphere
View Scheme
bromoacetic acid
79-08-3

bromoacetic acid

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate
1351451-82-5

6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate

Conditions
ConditionsYield
Stage #1: bromoacetic acid; 17-propionate carbothioic acid With triethylamine In acetone at 25℃; for 5h;
Stage #2: With hydrogenchloride In water; acetone at 0℃; pH=1 - 1.5;
97.1%
With triethylamine In dichloromethane at 20℃;
17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbonylsulfenic acid
948566-12-9

6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbonylsulfenic acid

Conditions
ConditionsYield
With water; urea In methanol at 10 - 15℃; for 1h;96.22%
With dihydrogen peroxide In methanol at 10 - 20℃; for 1h;96.22%
bromofluoromethane
373-52-4

bromofluoromethane

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at -10 - 20℃; for 2h;91.7%
With potassium carbonate In acetone at -5 - 0℃; for 2 - 5h; Product distribution / selectivity;84.51%
Stage #1: 17-propionate carbothioic acid With potassium carbonate In acetone at 20℃; for 0.5h;
Stage #2: bromofluoromethane In acetone at 0 - 5℃;
80%
fluoroiodomethane
373-53-5

fluoroiodomethane

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃; for 6h; chemoselective reaction;82%
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 22 - 25℃; for 0.25h;67.1%
With potassium carbonate; sodium hydrogensulfite In acetone at -10℃;
N-ethyl-N,N-diisopropylamine
7087-68-5

N-ethyl-N,N-diisopropylamine

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methylpregna-3-oxo-1,4-diene-17β-thiocarboxylic acid diisopropylethylamine salt

6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methylpregna-3-oxo-1,4-diene-17β-thiocarboxylic acid diisopropylethylamine salt

Conditions
ConditionsYield
In isopropyl alcohol at 5 - 25℃; for 3.25h;82%
In isopropyl alcohol at 5 - 25℃; for 3.25h;82%
chlorobromomethane
74-97-5

chlorobromomethane

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

S-chloromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate
80486-69-7

S-chloromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl acetamide for 2h;67%
Stage #1: 17-propionate carbothioic acid With sodium hydrogencarbonate In acetonitrile at 5℃; for 0.5h;
Stage #2: chlorobromomethane In acetonitrile at 5 - 25℃; for 12h;
(10-bromodecyl)phosphonic acid

(10-bromodecyl)phosphonic acid

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

(10-(((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyl-oxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)decyl)phosphonic acid

(10-(((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyl-oxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)decyl)phosphonic acid

Conditions
ConditionsYield
Stage #1: (10-bromodecyl)phosphonic acid; 17-propionate carbothioic acid In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere;
Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;
63%
Stage #1: (10-bromodecyl)phosphonic acid; 17-propionate carbothioic acid at 25℃; for 0.166667h; Inert atmosphere;
Stage #2: With N-ethyl-N,N-diisopropylamine at 25℃; Inert atmosphere;
63%
17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

17,17'-(trisulfanediyldicarbonyl)bis(6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-yl) dipropanoate
960071-64-1

17,17'-(trisulfanediyldicarbonyl)bis(6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-yl) dipropanoate

Conditions
ConditionsYield
With thioacetic acid S-ethoxydisulfanyl ester In tetrachloromethane; dichloromethane for 8h; Reflux;42%
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(5-methyl-2-oxo-1,3-dioxol4-ylmethyl) ester

6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(5-methyl-2-oxo-1,3-dioxol4-ylmethyl) ester

Conditions
ConditionsYield
With potassium carbonate In diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide27%
2-buten-4-olide
497-23-4

2-buten-4-olide

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

6α,9α-Difluoro-11α-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-4-yl) ester

6α,9α-Difluoro-11α-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-4-yl) ester

Conditions
ConditionsYield
With potassium carbonate In ethyl acetate; N,N-dimethyl-formamide3%
17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

[18F]fluoromethylene toluene-4-sulfonate
113426-16-7

[18F]fluoromethylene toluene-4-sulfonate

[18F]fluticasone propionate

[18F]fluticasone propionate

Conditions
ConditionsYield
In acetonitrile at 110℃; for 0.333333h;
With potassium carbonate In acetonitrile at 110℃; for 0.75h;
17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h
2: 85 percent / NaI / acetone / Heating
3: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 3 h / 20 °C
2: triethylamine / dmap / tetrahydrofuran / 20 °C
3: trifluoroacetic acid / 2 h / 20 °C
4: xenon fluoride / dichloromethane / 48 h / -10 °C
5: ammonia; methanol / 0.08 h / 0 °C
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 3 h / 20 °C
2: triethylamine; dmap / tetrahydrofuran / 20 °C
3: trifluoroacetic acid / 2 h / 20 °C
4: xenon difluoride / dichloromethane / 48 h / -10 °C
5: ammonia / methanol / 0.08 h / 0 °C
View Scheme
17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

S-iodomethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxo-androsta-1,4-diene-17β-carbothioate
80474-67-5

S-iodomethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxo-androsta-1,4-diene-17β-carbothioate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h
2: 85 percent / NaI / acetone / Heating
View Scheme
formaldehyd
50-00-0

formaldehyd

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

S-hydroxymethyl 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate
709002-83-5

S-hydroxymethyl 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

Conditions
ConditionsYield
In dichloromethane; water at 0℃; for 1h;
17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

flixotide
80474-14-2

flixotide

Conditions
ConditionsYield
base;
With potassium thiosulfate; 2-methylacrylic acid 3-hydroxypropyl ester at 10℃;
morpholine
110-91-8

morpholine

N-methylcyclohexylamine
626-67-5

N-methylcyclohexylamine

cyclohexylamine
108-91-8

cyclohexylamine

diethylamine
109-89-7

diethylamine

triethylamine
121-44-8

triethylamine

N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

A

diethylammonium 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy;-17α-propionyloxyandrosta-1,4-diene-17β-thiocarboxylate

diethylammonium 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy;-17α-propionyloxyandrosta-1,4-diene-17β-thiocarboxylate

B

C4H9NO*C24H30F2O5S

C4H9NO*C24H30F2O5S

C

C6H13N*C24H30F2O5S

C6H13N*C24H30F2O5S

D

C12H23N*C24H30F2O5S

C12H23N*C24H30F2O5S

E

6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methyl-pregna-3-oxo-1,4-diene-17β-thiocarboxylic acid triethylamine salt

6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methyl-pregna-3-oxo-1,4-diene-17β-thiocarboxylic acid triethylamine salt

F

6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methyl-pregna-3-oxo-1,4-diene-17β-thiocarboxylic acid N-methylpiperidine salt

6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methyl-pregna-3-oxo-1,4-diene-17β-thiocarboxylic acid N-methylpiperidine salt

Conditions
ConditionsYield
Combinatorial reaction / High throughput screening (HTS);
α-methylene-γ-butyrolactone
547-65-9

α-methylene-γ-butyrolactone

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-3-ylmethyl) ester
219719-97-8

6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-3-ylmethyl) ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide
α-bromo-γ-butyrolactone
5061-21-2

α-bromo-γ-butyrolactone

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-3-yl) ester
629645-25-6

6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-3-yl) ester

Conditions
ConditionsYield
With potassium carbonate In ethyl acetate; N,N-dimethyl-formamide
2-bromo-1-tetralone
1056246-70-8

2-bromo-1-tetralone

17-propionate carbothioic acid
80474-45-9

17-propionate carbothioic acid

S-[1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl] 6α,9α-difluoro-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

S-[1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl] 6α,9α-difluoro-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

Conditions
ConditionsYield
With potassium carbonate In acetone at 25 - 30℃; for 3h;

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