(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carbothioic acid supplier

Name
FLUTICASONE PROPIONATE INTERMEDIATE
EINECS
CAS No. 80474-45-9
Article Data16
CAS DataBase
Density 1.315 g/cm³
Solubility 50mg/L at 20℃
Melting Point 158-160 °C
Formula C₂₄H₃₀F₂O₅S
Boiling Point 563.337 °C at 760 mmHg
Molecular Weight 468.562
Flash Point 294.496 °C
Transport Information
Appearance white solid
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms FLUTICASONE PROPIONATE INTERMEDIATE;6,9-DIFLUORO-11B-HYRDOXY-16-METHYL-3-OXO-17-PROPIONYLOXYANDROSTA-1,4-DIENE-17B-CARBPTHIOCACID;(6alpha,11beta,,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxo-propoxy)androsta-1,4-diene-17-carbothioic acid;6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-;Androsta-1,4-diene-17-carbothioic acid;oxopropoxy)-, (6α,11β,16α,17α)-;6a,9a-difluoro-l1~-hydroxy-l6a-methyl- 17a-propionyloxy-3-oxoandrosta-l,4-diene-l7~-carbothioic acid;(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carbothioic acid
PSA 119.47000
LogP 3.69960

Synthetic route

: 105638-31-1
17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
Stage #1: 17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene With methanol; potassium carbonate at 20℃; for 5 - 7h; Stage #2: With hydrogenchloride In water at 20℃; pH=1.5 - 2.0; Product distribution / selectivity;	96.33%
With calcium hydroxide In methanol at 25 - 30℃; for 24h; Reagent/catalyst;	96.3%
With potassium carbonate In methanol at 25℃; for 5h; Inert atmosphere;	95%

: 79-03-8
propionyl chloride

: 80473-92-3
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
Stage #1: propionyl chloride; 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid With triethylamine In dichloromethane at -5℃; Stage #2: With diethylamine In acetone for 1h; regioselective reaction;	91%
With pyridine In acetone at -20 - -15℃; Product distribution / selectivity;	88%
With 1-methyl-1H-imidazole In acetone at -20 - -15℃; Product distribution / selectivity;	88%

: 65429-42-7
6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylic acid

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
Stage #1: 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylic acid With 1-methyl-1H-imidazole In ISOPROPYLAMIDE at 50℃; Stage #2: With sodium hydrogensulfide In ISOPROPYLAMIDE at 35℃; for 0.25h; Stage #3: With hydrogenchloride In ISOPROPYLAMIDE; water pH=2;	32%
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 20 °C 2: Et2NH / Heating View Scheme
Multi-step reaction with 2 steps 1: sodium iodide; triethylamine / tetrahydrofuran / 4 h / 70 - 75 °C 2: morpholine / 3 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: triethylamine; sodium iodide / acetone; water / 6 h / 10 - 30 °C 1.2: 1 h / 0 °C 2.1: potassium carbonate / methanol / 5 h / 25 °C / Inert atmosphere View Scheme

: 577965-09-4
Propionic acid (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propionylsulfanylcarbonyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
With diethylamine In acetone for 1h; Yield given;

: 578740-28-0
C24H29F2O5S(1-)*K(1+)

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
With hydrogenchloride; water In methanol at 20℃; pH=1 - 2;

: 80473-92-3
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 0.75 h 2: Et2NH / acetone / 1 h View Scheme

: 28416-82-2
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: dimethylformamide / 4 h / Ambient temperature 2: H2S / dimethylformamide 3: Et3N / CH2Cl2 / 0.75 h 4: Et2NH / acetone / 1 h View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine / acetone / 3 h / 0 - 5 °C 1.2: 2.5 h / 40 - 45 °C 2.1: sodium iodide; triethylamine / tetrahydrofuran / 4 h / 70 - 75 °C 3.1: morpholine / 3 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine / acetone / 4 h / 10 - 25 °C 1.2: 10 - 25 °C 1.3: 0 °C / pH 1 - 1.5 2.1: triethylamine; sodium iodide / acetone; water / 6 h / 10 - 30 °C 2.2: 1 h / 0 °C 3.1: potassium carbonate / methanol / 5 h / 25 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine / acetone / 1 h / 0 - 10 °C 1.2: 2 h 2.1: sodium iodide; triethylamine / tetrahydrofuran / 16 h / 20 °C 3.1: calcium hydroxide / methanol / 24 h / 25 - 30 °C View Scheme

: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(imidazole-1-carbonyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: H2S / dimethylformamide 2: Et3N / CH2Cl2 / 0.75 h 3: Et2NH / acetone / 1 h View Scheme

: C28H33F2NO8

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
With sodium hydrogensulfide In ISOPROPYLAMIDE at 35℃; for 0.25h;

: 105638-31-1
17β-[(N,N-dimethylcarbamoyl)thio]formyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-one androstone-1,4-diene

A: 59860-80-9
methyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carboxylate

B: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
With methanol; potassium carbonate at 20℃; for 1 - 5h; Product distribution / selectivity;
With methanol; caesium carbonate at 20℃; for 1 - 5h; Product distribution / selectivity;

: 79-03-8
propionyl chloride

: 109-89-7
diethylamine

: 80473-92-3
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
With triethylamine In dichloromethane; ethyl acetate; acetone

...Expand

: 1892-31-5
propanethioic acid

: 28416-82-2
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
Stage #1: 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 5℃; for 18h; Inert atmosphere; Stage #2: propanethioic acid In tetrahydrofuran at 5 - 25℃; for 7h; Product distribution / selectivity; Inert atmosphere;

: 2135-17-3
flumetasone

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: sodium periodate / water; tetrahydrofuran / 2 h / 25 - 30 °C 2.1: triethylamine / acetone / 3 h / 0 - 5 °C 2.2: 2.5 h / 40 - 45 °C 3.1: sodium iodide; triethylamine / tetrahydrofuran / 4 h / 70 - 75 °C 4.1: morpholine / 3 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1.1: periodic acid / water; tetrahydrofuran / 2 h / 0 - 10 °C 2.1: triethylamine / acetone / 1 h / 0 - 10 °C 2.2: 2 h 3.1: sodium iodide; triethylamine / tetrahydrofuran / 16 h / 20 °C 4.1: calcium hydroxide / methanol / 24 h / 25 - 30 °C View Scheme

: 6α,9α-difluoro-11β, 17α-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione

: 80474-45-9
17-propionate carbothioic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: sodium hypobromide / 1,4-dioxane / 5 h / 8 °C 2.1: triethylamine / acetone / 4 h / 10 - 25 °C 2.2: 10 - 25 °C 2.3: 0 °C / pH 1 - 1.5 3.1: triethylamine; sodium iodide / acetone; water / 6 h / 10 - 30 °C 3.2: 1 h / 0 °C 4.1: potassium carbonate / methanol / 5 h / 25 °C / Inert atmosphere View Scheme

: 79-08-3
bromoacetic acid

: 80474-45-9
17-propionate carbothioic acid

: 1351451-82-5
6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate

Conditions

Conditions	Yield
Stage #1: bromoacetic acid; 17-propionate carbothioic acid With triethylamine In acetone at 25℃; for 5h; Stage #2: With hydrogenchloride In water; acetone at 0℃; pH=1 - 1.5;	97.1%
With triethylamine In dichloromethane at 20℃;

: 80474-45-9
17-propionate carbothioic acid

: 948566-12-9
6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbonylsulfenic acid

Conditions

Conditions	Yield
With water; urea In methanol at 10 - 15℃; for 1h;	96.22%
With dihydrogen peroxide In methanol at 10 - 20℃; for 1h;	96.22%

: 373-52-4
bromofluoromethane

: 80474-45-9
17-propionate carbothioic acid

: 80474-14-2
flixotide

Conditions

Conditions	Yield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at -10 - 20℃; for 2h;	91.7%
With potassium carbonate In acetone at -5 - 0℃; for 2 - 5h; Product distribution / selectivity;	84.51%
Stage #1: 17-propionate carbothioic acid With potassium carbonate In acetone at 20℃; for 0.5h; Stage #2: bromofluoromethane In acetone at 0 - 5℃;	80%

: 373-53-5
fluoroiodomethane

: 80474-45-9
17-propionate carbothioic acid

: 80474-14-2
flixotide

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 20℃; for 6h; chemoselective reaction;	82%
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 22 - 25℃; for 0.25h;	67.1%
With potassium carbonate; sodium hydrogensulfite In acetone at -10℃;

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 80474-45-9
17-propionate carbothioic acid

: 6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methylpregna-3-oxo-1,4-diene-17β-thiocarboxylic acid diisopropylethylamine salt

Conditions

Conditions	Yield
In isopropyl alcohol at 5 - 25℃; for 3.25h;	82%
In isopropyl alcohol at 5 - 25℃; for 3.25h;	82%

: 74-97-5
chlorobromomethane

: 80474-45-9
17-propionate carbothioic acid

: 80486-69-7
S-chloromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl acetamide for 2h;	67%
Stage #1: 17-propionate carbothioic acid With sodium hydrogencarbonate In acetonitrile at 5℃; for 0.5h; Stage #2: chlorobromomethane In acetonitrile at 5 - 25℃; for 12h;

: (10-bromodecyl)phosphonic acid

: 80474-45-9
17-propionate carbothioic acid

: (10-(((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyl-oxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)decyl)phosphonic acid

Conditions

Conditions	Yield
Stage #1: (10-bromodecyl)phosphonic acid; 17-propionate carbothioic acid In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere; Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	63%
Stage #1: (10-bromodecyl)phosphonic acid; 17-propionate carbothioic acid at 25℃; for 0.166667h; Inert atmosphere; Stage #2: With N-ethyl-N,N-diisopropylamine at 25℃; Inert atmosphere;	63%

: 80474-45-9
17-propionate carbothioic acid

: 960071-64-1
17,17'-(trisulfanediyldicarbonyl)bis(6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-yl) dipropanoate

Conditions

Conditions	Yield
With thioacetic acid S-ethoxydisulfanyl ester In tetrachloromethane; dichloromethane for 8h; Reflux;	42%

: 80715-22-6
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

: 80474-45-9
17-propionate carbothioic acid

: 6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(5-methyl-2-oxo-1,3-dioxol4-ylmethyl) ester

Conditions

Conditions	Yield
With potassium carbonate In diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide	27%

: 497-23-4
2-buten-4-olide

: 80474-45-9
17-propionate carbothioic acid

: 6α,9α-Difluoro-11α-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-4-yl) ester

Conditions

Conditions	Yield
With potassium carbonate In ethyl acetate; N,N-dimethyl-formamide	3%

: 80474-45-9
17-propionate carbothioic acid

: 113426-16-7
[18F]fluoromethylene toluene-4-sulfonate

: [18F]fluticasone propionate

Conditions

Conditions	Yield
In acetonitrile at 110℃; for 0.333333h;
With potassium carbonate In acetonitrile at 110℃; for 0.75h;

: 80474-45-9
17-propionate carbothioic acid

: 80474-14-2
flixotide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h 2: 85 percent / NaI / acetone / Heating 3: 74 percent / AgF / acetonitrile / 4 h / Ambient temperature View Scheme
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 3 h / 20 °C 2: triethylamine / dmap / tetrahydrofuran / 20 °C 3: trifluoroacetic acid / 2 h / 20 °C 4: xenon fluoride / dichloromethane / 48 h / -10 °C 5: ammonia; methanol / 0.08 h / 0 °C View Scheme
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 3 h / 20 °C 2: triethylamine; dmap / tetrahydrofuran / 20 °C 3: trifluoroacetic acid / 2 h / 20 °C 4: xenon difluoride / dichloromethane / 48 h / -10 °C 5: ammonia / methanol / 0.08 h / 0 °C View Scheme

: 80474-45-9
17-propionate carbothioic acid

: 80474-67-5
S-iodomethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxo-androsta-1,4-diene-17β-carbothioate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 67 percent / NaHCO3 / N,N-dimethyl-acetamide / 2 h 2: 85 percent / NaI / acetone / Heating View Scheme

: 50-00-0
formaldehyd

: 80474-45-9
17-propionate carbothioic acid

: 709002-83-5
S-hydroxymethyl 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

Conditions

Conditions	Yield
In dichloromethane; water at 0℃; for 1h;

: 593-70-4
R32

: 80474-45-9
17-propionate carbothioic acid

: 80474-14-2
flixotide

Conditions

Conditions	Yield
base;
With potassium thiosulfate; 2-methylacrylic acid 3-hydroxypropyl ester at 10℃;

: 110-91-8
morpholine

: 626-67-5
N-methylcyclohexylamine

: 108-91-8
cyclohexylamine

: 109-89-7
diethylamine

: 121-44-8
triethylamine

: 101-83-7
N-cyclohexyl-cyclohexanamine

: 80474-45-9
17-propionate carbothioic acid

A: diethylammonium 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy;-17α-propionyloxyandrosta-1,4-diene-17β-thiocarboxylate

B: C4H9NO*C24H30F2O5S

C: C6H13N*C24H30F2O5S

D: C12H23N*C24H30F2O5S

E: 6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methyl-pregna-3-oxo-1,4-diene-17β-thiocarboxylic acid triethylamine salt

F: 6α,9α-difluoro-11β-hydroxy-17α-propionyloxy-16α-methyl-pregna-3-oxo-1,4-diene-17β-thiocarboxylic acid N-methylpiperidine salt

Conditions

Conditions	Yield
Combinatorial reaction / High throughput screening (HTS);

...Expand

: 547-65-9
α-methylene-γ-butyrolactone

: 80474-45-9
17-propionate carbothioic acid

: 219719-97-8
6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-3-ylmethyl) ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide

: 5061-21-2
α-bromo-γ-butyrolactone

: 80474-45-9
17-propionate carbothioic acid

: 629645-25-6
6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-3-yl) ester

Conditions

Conditions	Yield
With potassium carbonate In ethyl acetate; N,N-dimethyl-formamide

: 1056246-70-8
2-bromo-1-tetralone

: 80474-45-9
17-propionate carbothioic acid

: S-[1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl] 6α,9α-difluoro-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

Conditions

Conditions	Yield
With potassium carbonate In acetone at 25 - 30℃; for 3h;

(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carbothioic acid Specification

The (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carbothioic acid, with the CAS registry number 80474-45-9, is also known as Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, (6α,11β,16α,17α)-. This chemical's molecular formula is C₂₄H₃₀F₂O₅S and molecular weight is 468.5538. Its systematic name is called (6α,11β,16α,17α)-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(propanoyloxy)androsta-1,4-diene-17-carbothioic S-acid.

Physical properties of (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carbothioic acid: (1)ACD/LogP: 2.67; (2)ACD/LogD (pH 7.4): -1; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 3; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 5; (8)#H bond donors: 1; (9)#Freely Rotating Bonds: 5; (10)Index of Refraction: 1.566; (11)Molar Refractivity: 116.238 cm³; (12)Molar Volume: 356.34 cm³; (13)Surface Tension: 49.269 dyne/cm; (14)Density: 1.315 g/cm³; (15)Flash Point: 294.496 °C; (16)Enthalpy of Vaporization: 97.273 kJ/mol; (17)Boiling Point: 563.337 °C at 760 mmHg; (18)Vapour Pressure: 0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(S)[C@]3(OC(=O)CC)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C
(2)InChI: InChI=1/C24H30F2O5S/c1-5-19(29)31-24(20(30)32)12(2)8-14-15-10-17(25)16-9-13(27)6-7-21(16,3)23(15,26)18(28)11-22(14,24)4/h6-7,9,12,14-15,17-18,28H,5,8,10-11H2,1-4H3,(H,30,32)/t12-,14+,15+,17+,18+,21+,22+,23+,24+/m1/s1
(3)InChIKey: QGESYFOFLPJDJW-CQRCZTONBZ

Product Name

FLUTICASONE PROPIONATE INTERMEDIATE

Synthetic route

(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carbothioic acid Specification

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