Add time:08/24/2019         Source:sciencedirect.com

A series of new 3-amino, 3-aminomethyl-5-alkoxy-3,4-dihydro-2H-1-benzopyran and 5′-alkoxy-3′,4′-dihydrospiro[piperazine-2,3′(2′H)-benzopyran] derivatives was prepared and evaluated for affinity at 5-HT1A, 5-HT2A and D2 receptors. Two of the compounds (Figure 3, Scheme 3, Figure 4, Scheme 4) can be considered as potent and selective 5-HT2A ligands. One compound (Figure 3, Scheme 3) demonstrated high affinity for 5-HT1A and D2 receptor binding sites and one compound (Figure 3, Scheme 2) proved to be a mixed 5-HT1A/5-HT2A ligand.

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