Asymmetric synthesis of (1R,2S)-2-fluorocyclopropylamine, the key intermediate of the new generation of quinolonecarboxylic acid, DU-6859-Science-Chemical Encyclopedia-lookchem

Asymmetric synthesis of (1R,2S)-2-fluorocyclopropylamine, the key intermediate of the new generation of quinolonecarboxylic acid, DU-6859
Add time:07/14/2019 Source:sciencedirect.com

The title synthesis was achieved by featuring diastereoface selective cyclopropanation of (4R,5S)-4,5-diphenyl-3-vinyl-2-oxazolidinone, the chiral and conformationally rigid N-vinylcarbamate, with zinc-monofluorocarbenoid followed by hydrogenolysis of formed (4R,5S)-3-[(1R-2S)-2-fluorocyclopropyl]-4,5-diphenyl-2-oxalidinone.

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