Add time:07/13/2019         Source:sciencedirect.com

In aqueous solution, aspartame can cyclicize to form its corresponding diketopiperazine (3-carboxymethyl-6-benzyl-2,5-diketopiperazine; DKP) and methanol. We measured plasma and urinary concentrations of DKP in samples obtained from six normal adult subjects ingesting 2.2 mg DKP/kg body weight. The DKP was administered as part of a dose of 200 mg aspartame/kg body weight. DKP concentrations in plasma were below the detection limit (< 1 μg/ml) of the high-pressure liquid chromatographic method at each time interval after ingestion at which they were measured. Mean (± SD) total urinary DKP excreted during the first 24-hr period after dosing was 6.68 ± 1.30 mg (4.83 ± 0.23% of the ingested DKP dose). Approximately 44% of the total DKP excreted was excreted in the first 4 hr after dosing.

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