Add time:08/25/2019         Source:sciencedirect.com

Publisher SummaryThis chapter focuses on pharmacologically active pyridazine derivatives. This chapter describes that the cardiovascular diseases occupy first place as causa mortis in civilized countries continues to influence strongly the research in the field of bioactive pyridazine derivatives, as shown by the enormous number of patents and papers dealing with pyridazines useful as cardiovascular drugs. Cardiovascular active pyridazines are divided into the following classes: cardiotonics (including pyridazines exhibiting both positive inotropic and systemic vasodilator activity—that is, inodilators), coronary vasodilators, antiarrhythmics, cardioselective P-blockers, antihypertensive agents, antihypotensive agents, and hypocholesterolaemic agents. The increasing interest in the chemistry and in biological activities of pyridazines as observed within the past 15 years has resulted in the development of a wide variety of interesting novel drugs and pharmacological tools. It is hoped that this chapter will not only facilitate the access to the literature on pharmacologically interesting pyridazines but also stimulate further research in this field.

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