Add time:08/31/2019         Source:sciencedirect.com

Phytochemical investigation of the aerial parts of Glaucium arabicum Fresen. (Papaveraceae) led to the isolation of two previously undescribed Isoquinoline (cas 119-65-3) alkaloids araglaucine A, and araglaucine B, together with seven known ones 1-[(3`,4`-dimethoxy-2`-methylcarboxy)benzoyl]-6,7-methylenedioxy isoquinoline (araglaucine C), (7R,14S)-trans-N-methylcanadinium nitrate, (R,S)-trans-N-methylstylopine, 14-hydroxy-N-methyl canadine, 14-hydroxy-N-methyl stylopine, protopine, norsanguinarine, as well as β-sitosterol, and β-sitosterol 3-O-β–d-glucoside. Their structural elucidation was based on the measurements of 1D, 2D NMR, HRESIMS, UV, IR and X-ray crystallography. The compounds were evaluated for their anti-melanogenesis activity using B16 melanoma cell lines. Compound (7R,14S)-trans-N-methylcanadinium nitrate exhibited a promising melanin synthesis inhibitory activity (∼35%) at concentration 5 μg/ml (12.01 μM) with low cytotoxicity (∼12%).

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