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Cas:119-65-3
Min.Order:1 Metric Ton
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Type:Manufacturers
inquiryProduct description: Product name Isoquinoline CAS number 119-65-3 Assay ≥99% Appearance Colorless to yellowish liquid or crystal Capacity 500mt/year Application Pharmaceutic
Cas:119-65-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
About Product Details Isoquinoline Chemical Properties
Cas:119-65-3
Min.Order:1 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryProName:119-65-3 Isoquinoline CasNo:119-65-3 Molecular Formula:C9H7N Appearance:White Powder Application:API,Pharmaceutical intermediates DeliveryTime:In Stock PackAge:25KGS/Drum Port:Shanghai ProductionCapacity:10 Metric Ton/Month Purity:
Cas:119-65-3
Min.Order:1 Kilogram
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inquiryTianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationship
Cas:119-65-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:119-65-3
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryName Isoquinoline Synonyms Isoquinoline Molecular Formula C9H7N CAS Registry Number 119-65-3 LC content 99% Application
Cas:119-65-3
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiryAppearance:Light brown powder Storage:2-8°C Package:25kg/drum Application:Isoquinolines are used in the manufacture of dyes, paints, insecticides and antifungals. It is also used as a solvent for the extraction of resins and terpenes, and as a corr
Cas:119-65-3
Min.Order:1 Kilogram
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:119-65-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:119-65-3
Min.Order:10 Gram
FOB Price: $1.32
Type:Trading Company
inquiryProduct Name: Isoquinoline CAS: 119-65-3 MF: C9H7N MW: 129.16 EINECS: 204-341-8 Mol File: 119-65-3.mol Isoquinoline Structure Isoquinoline Chemical Properties Melting point 26-28 °C (lit.) Boiling point 242-243 °C
Isoquinoline CAS: 119-65-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:119-65-3
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:119-65-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:119-65-3
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryCompany information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big cust
Cas:119-65-3
Min.Order:1 Kilogram
FOB Price: $7.0 / 10.0
Type:Trading Company
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:119-65-3
Min.Order:1 Kilogram
FOB Price: $40.0 / 50.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual
Cas:119-65-3
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:119-65-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirymoderate price & quick delivery Appearance:light brown low meltling solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Spices.Is used to m
Product name: Isoquinoline CAS No.: 119-65-3 Molecule Formula:C9H7N Molecule Weight:129.16 Purity: 98.0% Package: 200kg/drum Description:Brown oil-like liquid Manufacture Standards:Enterprise Standard TESTING ITEMS
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Conditions | Yield |
---|---|
With chlorosulfonic acid at 100℃; for 0.166667h; | 100% |
With C22H22Cl2FeN2O8(2-)*2C16H36N(1+); oxygen In neat (no solvent) at 100℃; under 760.051 Torr; for 1h; Green chemistry; | 99% |
isoquinoline-N-oxide hydrate
isoquinoline
Conditions | Yield |
---|---|
With titanium tetrachloride; tin(ll) chloride In benzene for 0.5h; Ambient temperature; | 98% |
Conditions | Yield |
---|---|
With manganese(IV) oxide at 105℃; for 0.0416667 - 0.0666667h; Inert atmosphere; Microwave irradiation; | 97% |
With ethene; 5%-palladium/activated carbon In 5,5-dimethyl-1,3-cyclohexadiene at 150℃; under 760.051 Torr; for 1h; Molecular sieve; Autoclave; | 92% |
With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II) In 1,3,5-trimethyl-benzene at 165℃; for 24h; Inert atmosphere; | 91% |
Conditions | Yield |
---|---|
With palladium on activated charcoal; tetrabutylammomium bromide; water; sodium hydroxide; silicon at 100℃; for 6h; Reagent/catalyst; | 97% |
With ammonium formate; palladium on activated charcoal In methanol at 40℃; for 0.25h; | 96% |
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate In acetonitrile at 20℃; for 0.0833333h; Inert atmosphere; Irradiation; chemoselective reaction; | 96% |
Conditions | Yield |
---|---|
With [Au(1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene)(O2CAd)] In toluene at 120℃; for 16h; | 97% |
With acetic acid; silver carbonate In dimethyl sulfoxide at 120℃; for 16h; | 92% |
With methanol at 40℃; for 48h; Schlenk technique; Irradiation; Inert atmosphere; | 72% |
In 1-methyl-pyrrolidin-2-one at 170℃; for 16h; Inert atmosphere; | 98 %Chromat. |
Conditions | Yield |
---|---|
With pyridine hydrochloride for 10h; Heating; | 96% |
With sulfolane; triphenylphosphine at 151℃; Rate constant; |
1-chloroisoquinoline
isoquinoline
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 25℃; for 3h; Inert atmosphere; | 95% |
With phosphorus; hydrogen iodide at 170 - 180℃; | |
With ZnSe/CdS core/shell QDs; N-ethyl-N,N-diisopropylamine In hexane at 25℃; for 24h; Irradiation; Inert atmosphere; | 33 %Chromat. |
Conditions | Yield |
---|---|
With potassium tert-butylate In decane at 150℃; for 36h; Inert atmosphere; Schlenk technique; | 93% |
With potassium tert-butylate In o-xylene at 140℃; for 36h; Inert atmosphere; | 90% |
With palladium at 190℃; | |
With [iPrPN(H)P]2Fe(H)(CO)(BH4) In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 30h; Inert atmosphere; Schlenk technique; Glovebox; |
1,2-dihydro-2-phenoxycarbonylisoquinoline-1-carbonitrile
benzoic acid
A
isoquinoline
B
benzoic acid phenyl ester
Conditions | Yield |
---|---|
at 135℃; for 2.5h; | A 77% B 92% |
5,6,7,8-tetrahydroisoquinoline
isoquinoline
Conditions | Yield |
---|---|
With ethene; 5%-palladium/activated carbon In 5,5-dimethyl-1,3-cyclohexadiene at 150℃; under 760.051 Torr; for 8h; Molecular sieve; Autoclave; | 92% |
Conditions | Yield |
---|---|
With sodium hydroxide In water for 24h; | A 91% B 87% |
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 25℃; for 1h; Inert atmosphere; | 91% |
With potassium tert-butylate; benzyl alcohol In N,N-dimethyl-formamide at 30℃; for 3h; Reagent/catalyst; Schlenk technique; Inert atmosphere; | 84% |
With triethylamine In methanol; water at 4℃; for 24h; Irradiation; sensitizer: methylene blue; | 67% |
With hydrogen; triethylamine In methanol; water at 120℃; under 22502.3 Torr; for 24h; Autoclave; | 59% |
With isopropyl alcohol In N,N-dimethyl-formamide at 20℃; for 36h; UV-irradiation; chemoselective reaction; | 54% |
Conditions | Yield |
---|---|
With potassium tert-butylate; N,N-dimethyl-formamide at 35℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; | 91% |
2,5-Dimethylphenol
5-bromoisoquinoline
A
isoquinoline
B
5-(2,5-dimethylphenoxy)isoquinoline
Conditions | Yield |
---|---|
With 2-Picolinic acid; potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; | A 10% B 89% |
Conditions | Yield |
---|---|
With potassium tert-butylate; N,N-dimethyl-formamide at 35℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; | 89% |
methanol
A
isoquinoline
B
13-methoxy-8H-dibenzoquinolizin-8-one
C
dimethyl 2--1,2-dihydro-1-isoquinolylphosphonate
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran Mechanism; Product distribution; 1) - 70 deg C, 0.5 h, 2) room temperature, overnight; | A 87% B 18% C 62% |
With o-phthalic dicarboxaldehyde; lithium diisopropyl amide 1) THF, -50 - -60 deg C, 40 min, 2) -65 deg C, 0.5 h, then 40 deg C, 0.5 h; Yield given. Multistep reaction. Yields of byproduct given; |
1,2,3,4-tetrahydroisoquinoline
A
isoquinoline
B
3,4-dihydroisoquinolin-1(2H)-one
Conditions | Yield |
---|---|
With sodium hydroxide In water; tert-butyl alcohol for 24h; Reflux; | A 7% B 85% |
With sodium hypochlorite; racemic (salen)Mn(III) In dichloromethane at 0℃; for 4h; | A n/a B 27% |
With C47H15F20N5Zn; oxygen for 1.5h; Irradiation; Green chemistry; | A 13 %Spectr. B 36 %Spectr. |
methanol
A
isoquinoline
B
phthalic acid dimethyl ester
C
13-methoxy-8H-dibenzoquinolizin-8-one
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran Mechanism; Product distribution; 1) - 70 deg C, 0.5 h, 2) room temperature, overnight; | A 84% B n/a C 12% D 56% |
ethanol
A
isoquinoline
B
13-ethoxy-8H-dibenzoquinolizin-8-one
C
dimethyl 2--1,2-dihydro-1-isoquinolylphosphonate
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran Mechanism; Product distribution; 1) - 70 deg C, 0.5 h, 2) room temperature, overnight; | A 84% B 43% C n/a |
Conditions | Yield |
---|---|
With manganese(IV) oxide In dichloromethane for 24h; Ambient temperature; | A 8% B 83% |
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(l) chloride In neat (no solvent) at 60℃; for 60h; | A 12% B 81% |
With iodosylbenzene In dichloromethane for 0.5h; Ambient temperature; molecular sieves (4 A); | A 15% B 78% |
1,2,3,4-tetrahydroisoquinoline
A
isoquinoline
B
3,4-dihydroisoquinoline
C
3,4-dihydroisoquinolin-1(2H)-one
Conditions | Yield |
---|---|
With sodium periodate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; acetic acid In water; acetonitrile for 20h; | A 8% B 83% C 8% |
With 1-(tert-butylperoxy)-1,2-benziodoxol-3(1H)-one In benzene for 120h; Ambient temperature; | A 8% B 36% C 11% |
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccasefrom Trametes versicolor; oxygen In water at 30℃; for 168h; pH=4.5; Enzymatic reaction; | |
With C47H15F20N5Zn; oxygen for 1h; Irradiation; Green chemistry; | A 12 %Spectr. B 11 %Spectr. C 40 %Spectr. |
3-chloroisoquinoline
isoquinoline
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 60℃; for 8h; Inert atmosphere; | 82% |
isoquinoline
Conditions | Yield |
---|---|
With bis[dicarbonylcyclopentadienylruthenium(I)] In tetrahydrofuran-d8 at 20℃; for 2h; Irradiation; Inert atmosphere; | 80% |
2-benzoyl-1-cyano-1,2-dihydroisoquinoline
A
isoquinoline
B
pyridine-2-carboxylic acid amide
C
benzoic acid
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 1h; | A 78% B 17% C 29% |
1,2,3,4-tetrahydroisoquinoline
carbon dioxide
A
isoquinoline
B
3,4-dihydroisoquinoline
C
formic acid
Conditions | Yield |
---|---|
With bis(2,2'-bipyridyl-4,4'-dicarboxylic acid)ruthenium(II) dichloride In acetonitrile at 20℃; for 24h; Schlenk technique; Irradiation; Sealed tube; Green chemistry; | A 8.8% B 76.2% C 61.8 μmol |
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol for 2.5h; Heating; | A n/a B 75% |
With potassium hydroxide In ethanol for 2.5h; Heating; | A n/a B 75% |
8-chloroisoquinoline
isoquinoline
Conditions | Yield |
---|---|
With potassium tert-butylate; N,N-dimethyl-formamide at 35℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; | 75% |
ethanol
A
isoquinoline
B
13-ethoxy-8H-dibenzoquinolizin-8-one
C
diethyl 2--1,2-dihydro-1-isoquinolylphosphonate
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran Mechanism; Product distribution; 1) - 70 deg C, 0.5 h, 2) room temperature, overnight; | A 74% B 26% C 55% |
1-cyano-2-dimethylcarbamoyl-1,2-dihydroisoquinoline
isoquinoline
Conditions | Yield |
---|---|
With hydrogen bromide In acetic acid at 100℃; for 3h; other reagent (40percent KOH); | 74% |
Conditions | Yield |
---|---|
In methanol for 336000h; Heating; | 100% |
In acetone; benzene at 20℃; for 24h; | 100% |
In methanol for 336h; Heating; | 100% |
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; Inert atmosphere; | 100% |
With 3,3-dimethyldioxirane In acetone at 23℃; Kinetics; | 98% |
With 2,2,2-Trifluoroacetophenone; dihydrogen peroxide; acetonitrile In tert-butyl alcohol at 20℃; for 18h; Green chemistry; chemoselective reaction; | 97% |
Conditions | Yield |
---|---|
With sulfuric acid; potassium nitrate at -15 - 20℃; for 3.3h; | 100% |
Stage #1: isoquinoline With sulfuric acid; potassium nitrate at -15 - 20℃; Stage #2: With ammonium hydroxide In water at 0℃; pH=8; | 94% |
With sulfuric acid; potassium nitrate at -15 - 20℃; for 2h; | 94% |
isoquinoline
4-chlorobenzoylmethyl bromide
2-(2-(4-chlorophenyl)-2-oxoethyl)isoquinolin-2-ium bromide
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 0.333333h; | 100% |
In dichloromethane at 20℃; for 24h; | |
With cetyltrimethylammonim bromide In water at 20℃; for 0.5h; |
isoquinoline
p-benzyloxybenzaldehyde
4-(p-benzyloxybenzyl)isoquinoline
Conditions | Yield |
---|---|
Stage #1: isoquinoline With sodium triethylborohydride In tetrahydrofuran for 0.5h; Inert atmosphere; Stage #2: p-benzyloxybenzaldehyde In tetrahydrofuran for 4h; Inert atmosphere; Stage #3: With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran at 0℃; Inert atmosphere; | 100% |
isoquinoline
1‐cyclohexylisoquinoline
Conditions | Yield |
---|---|
With tris(2,2'-bipyridyl)ruthenium dichloride; toluene-4-sulfonic acid In N,N-dimethyl-formamide at 20℃; for 48h; Reagent/catalyst; Solvent; Minisci Aromatic Substitution; Inert atmosphere; Irradiation; | 100% |
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; trifluoroacetic acid In N,N-dimethyl acetamide at 20℃; for 5h; Reagent/catalyst; Irradiation; Inert atmosphere; Electrochemical reaction; | 90% |
With tetrakis(actonitrile)copper(I) hexafluorophosphate; 2.9-dimethyl-1,10-phenanthroline; zinc trifluoromethanesulfonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In N,N-dimethyl acetamide for 24h; Inert atmosphere; Irradiation; | 88% |
isoquinoline
trimethylsilyl cyanide
isobutyl chloroformate
1-cyano-2-isobutoxycarbonyl-1,2-dihydroisoquinoline
Conditions | Yield |
---|---|
In dichloromethane overnight; | 99% |
isoquinoline
chloroformic acid ethyl ester
1-(trimethylsilyloxy)cyclopentene
Conditions | Yield |
---|---|
In dichloromethane at 0℃; for 0.5h; | 99% |
isoquinoline
O-(2,4-dinitrophenyl)hydroxylamine
Conditions | Yield |
---|---|
In acetonitrile at 40℃; | 99% |
isoquinoline
phenyl isocyanate
dimethyl acetylenedicarboxylate
dimethyl 2-oxo-1-phenyl-1,11b-dihydro-2H-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylate
Conditions | Yield |
---|---|
In dichloromethane at -5 - 20℃; for 1.16667h; | 99% |
isoquinoline
2-chloro-4-isocyanato-1-methylbenzene
dimethyl acetylenedicarboxylate
Conditions | Yield |
---|---|
In dichloromethane at -5 - 20℃; for 1.16667h; | 99% |
isoquinoline
8,9-dimethoxy-1,2,3,11b-tetrahydrochromeno[4,3,2-de]isoquinoline
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydrogencarbonate; acetic acid | 99% |
isoquinoline
4-hydroxy[1]benzopyran-2-one
Cyclohexyl isocyanide
C25H24N2O3
Conditions | Yield |
---|---|
In water at 70℃; for 12h; | 99% |
isoquinoline
Conditions | Yield |
---|---|
In dichloromethane (N2, Schlenk) CH2Cl2 was added followed by AgSbF6 to Rh-complex under a stream of N2, the amine was added to the mixt. by syringe, stirred for 1h; filtered, the solvent was removed under vac., the residue was washed with pentane and dried under vac.; elem. anal.; | 99% |
isoquinoline
Conditions | Yield |
---|---|
In dichloromethane (N2, Schlenk) CH2Cl2 was added followed by AgSbF6 to Rh-complex under a stream of N2, the amine was added to the mixt. by syringe, stirred for 1h; filtered, the solvent was removed under vac., the residue was washed with pentane and dried under vac.; elem. anal.; | 99% |
isoquinoline
1-methyl-1,3-bis(trimethylsilyloxy)buta-1,3-diene
benzyl chloroformate
Conditions | Yield |
---|---|
In dichloromethane at 0 - 20℃; for 14h; regioselective reaction; | 99% |
isoquinoline
benzyl chloroformate
1-[3-(2-methoxyethoxycarbonyl)-2-oxopropyl]-1H-isoquinoline-2-carboxylic acid benzyl ester
Conditions | Yield |
---|---|
In dichloromethane at 0 - 20℃; for 14h; regioselective reaction; | 99% |
isoquinoline
N-phthalimide l-valinyl chloride
2-tert-butyldimethylsilyloxyfuran
Conditions | Yield |
---|---|
In dichloromethane at -78 - 20℃; for 18h; Mannich asymmetric reaction; Inert atmosphere; optical yield given as %de; diastereoselective reaction; | 99% |
isoquinoline
propynoic acid methyl ester
methyl (E)-3-(1-(3-methoxy-3-oxoprop-1-yn-1-yl)isoquinolin-2(1H)-yl)acrylate
Conditions | Yield |
---|---|
In neat (no solvent) at 60℃; for 0.166667h; | 99% |
With copper dichloride In dichloromethane at 20℃; for 1h; Inert atmosphere; | 90% |
isoquinoline
diphenyl hydrogen phosphite
2-chloro-4-isocyanato-1-methylbenzene
diphenyl {2-{[(3-chloro-4-methylphenyl)amino]carbonyl}-1,2-dihydroisoquinolin-1-yl}phosphonate
Conditions | Yield |
---|---|
at 20℃; for 0.0666667h; | 99% |
isoquinoline
2-bromo-1-cyclopropylethan-1-one
2-(2-cyclopropyl-2-oxoethyl)isoquinolin-2-ium bromide
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 48.5h; | 99% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 25℃; for 0.5h; Inert atmosphere; regioselective reaction; | 99% |
isoquinoline
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
Conditions | Yield |
---|---|
With C28H29NiOP In benzene-d6 at 30℃; for 2h; regioselective reaction; | 99% |
With [((2,6-iPr2-C6H3)NC(Me)CHP(Cy2)N(2,6-Me2-C6H3))MgH]2; methyltriphenylsilane In benzene-d6 at 25℃; Catalytic behavior; regioselective reaction; | 91% |
With C22H27N3 In benzene-d6 at 20℃; for 12h; Schlenk technique; | 80% |
Conditions | Yield |
---|---|
In acetonitrile at -15 - 20℃; for 1h; Mannich Aminomethylation; Inert atmosphere; diastereoselective reaction; | 99% |
Conditions | Yield |
---|---|
With Selectfluor; trifluoroacetic acid In acetonitrile at 25℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; | 99% |
With sodium persulfate; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; trifluoroacetic acid In water at 23℃; for 4h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation; regioselective reaction; | 88% |
With dipotassium peroxodisulfate; trifluoroacetic acid In water; acetonitrile for 2h; Solvent; Minisci Aromatic Substitution; Reflux; | 68% |
isoquinoline
1-(tert-butyldimethylsilyl)-5-methyl-1H-indole
tert-butyldicarbonate
Conditions | Yield |
---|---|
With (S)-3,3'-bis(9-anthracenyl)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate In para-xylene at 20℃; for 48h; enantioselective reaction; | 99% |
isoquinoline
tert-butyldicarbonate
1-(tert-Butyldimethylsilyl)-5-methoxyindole
Conditions | Yield |
---|---|
With (S)-3,3'-bis(9-anthracenyl)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate In para-xylene at 20℃; for 48h; enantioselective reaction; | 99% |
isoquinoline
tert-butyldicarbonate
1-(tert-butyldimethylsilanyl)-5-fluoro-1H-indole
Conditions | Yield |
---|---|
With (S)-3,3'-bis(9-anthracenyl)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate In para-xylene at 20℃; for 96h; enantioselective reaction; | 99% |
isoquinoline
tert-butyldicarbonate
Conditions | Yield |
---|---|
With (S)-3,3'-bis(9-anthracenyl)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate In para-xylene at 20℃; for 96h; enantioselective reaction; | 99% |
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