Add time:08/29/2019         Source:sciencedirect.com

Publisher SummaryThis chapter explores the biogenesis and metabolism of folic acid and vitamin B12. The biosynthesis of folic acid by microorganisms the aromatic ring of the p-aminobenzoic acid group is formed from carbohydrate via shikimic acid. Glutamic acid is possibly added after p-aminobenzoic acid has combined with the pteridine group of the molecule. The close biogenetic relationship that appears to exist between folic acid and riboflavin is further borne out by a recent study of Clapper and Meade who found that when the amount of folic acid required for growth of a strain of Streptococcus faecalis was limiting, the amount of riboflavin synthesized by the organism was depressed. This relationship also held in nonproliferating cells. Folic acid may be degraded to a pteridine that can be utilized for riboflavin synthesis. It may be possible that the folic acid component of the various coenzymes involved in single-carbon transfer reactions occurs in combination with additional amino acids attached by peptide linkage to the glutamic acid group.

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