Add time:08/30/2019         Source:sciencedirect.com

The reaction of dimethyl 2-(tosylmethyl)fumarate (6), prepared by iodosulfonylation-dehydroiodination of dimethyl itaconate, with carbonucleophiles or sodium methoxide allows the direct synthesis of 3-substituted itaconate ester derivatives 8 via a SN2′ pathway. When sodium thiolates are used as nucleophiles dimethyl 2-(alkylthiomethyl)fumarates 9 or alkylthiomethylene butanoates 10 are obtained via a double SN2′ process. In the case of pyrrolidine and cyclopentanone enamine, the corresponding diamino derivative 11 and the bicyclic[3.2.1]ketones 12 are obtained, respectively.

We also recommend Trading Suppliers and Manufacturers of (-)-BIS[(S)-1-(ETHOXYCARBONYL)ETHYL] FUMARATE (cas 111293-23-3). Pls Click Website Link as below: cas 111293-23-3 suppliers