2,2′-Isopropylidenebis[(4S,5R)-4,5-di(2-naphthyl)-2-oxazoline] ligand for asymmetric cyclization–carbonylation of meso-2-alkyl-2-propargylcyclohexane-1,3-diols-Science-Chemical Encyclopedia-lookchem

2,2′-Isopropylidenebis[(4S,5R)-4,5-di(2-naphthyl)-2-oxazoline] ligand for asymmetric cyclization–carbonylation of meso-2-alkyl-2-propargylcyclohexane-1,3-diols
Add time:09/05/2019 Source:sciencedirect.com

The oxidative cyclization–carbonylation of meso-2-alkyl-2-propargylcyclohexane-1,3-diols mediated by Pd(II) with chiral bisoxazoline (box ligand) afforded bicyclic-β-alkoxyacrylates. Based on a ligand screening, 2,2′-isopropylidenebis[(4S,5R)-4,5-di(2-naphthyl)-2-oxazoline] ligand has been developed. The products with a chiral quaternary carbon were obtained in 71–100% yields with 85–95% ee.

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