Add time:09/04/2019         Source:sciencedirect.com

This chapter describes methods of synthesis, the pharmacological properties, and the use of derivatives of piperidine-based nonfused biheterocycles with C–N and C–C coupling.Piperidine-based nonfused biheterocycles with C–N coupling are presented as a series of drugs such as droperidol, benperidol, timiperone, pimozide, zaldaride, domperidone, and bezitramide—compounds that are effective as antipsychotic agents.Two compounds of this series, benzpiperylon and piperylon, have analgesic and antipyretic properties.Piperidine-based nonfused biheterocycles with C–C coupling are presented by atypical antipsychotic drugs such as risperidone, paliperidone, and iloperidone. Sertindole, a second-generation atypical antipsychotic, and naratriptan, which belongs to a family of triptans, and indicated for the treatment of migraine headaches, are two other representatives of piperidine-based nonfused biheterocycle with C–C coupling.

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