Add time:08/31/2019         Source:sciencedirect.com

Binding of i.v. administered (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ([3H]3-PPP) in the brain of intact mice is antagonized dose responsively by σ receptor ligands. The correlation of potencies for inhibition of binding in vivo and in vitro indicates that σ receptors in mouse brain are labeled in vivo by i.v. [3H]3-PPP. 3-PPPP, the N-phenylpropyl derivative of norpropyl-3-PPP exhibits very high affinity for σ receptors in vitro and in vivo.

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