Synthesis and structure–activity relationships of a new series of 2α-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as μ-selective opioid antagonists-Science-Chemical Encyclopedia-lookchem

Synthesis and structure–activity relationships of a new series of 2α-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as μ-selective opioid antagonists
Add time:09/01/2019 Source:sciencedirect.com

Structure–activity relationships at the 2α-position of the piperidine ring of the trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine μ-opioid antagonist series were investigated. This study showed that only small linear alkyl groups (methyl, propyl) are tolerated at the 2α-position of the piperidine ring of this series.

We also recommend Trading Suppliers and Manufacturers of 3-(3-hydroxyphenyl)-N-(2-phenethyl)piperidine (cas 19725-24-7). Pls Click Website Link as below: cas 19725-24-7 suppliers

Prev:Short communication(+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)-piperidine binding to σ receptors in mouse brain in vivo
Next: Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles)

Click to view details

Encyclopedia