Add time:09/01/2019         Source:sciencedirect.com

Ascosin, a heptaene antibiotic produced by Streptomyces canescus (NRRL 2419) which inhibited yeast respiration completely, had no effect on glycolysis. Ascosin did not inhibit the reduction of the dye, 2,6-dichlorophenol indophenol with succinate as the substrate. Nor did it inhibit the oxidation of reduced cytochrome c by yeast extracts. The reduction of 2,3,5-triphenyltetrazolium chloride, which accepts electrons from cytochrome a, was completely inhibited by ascosin when succinate was the substrate. Ascosin also inhibited the succinate → cytochrome c reductase system. Mixtures of ascosin and antimycin-A at low concentrations produced inhibition that was even greater than the sum of the individual inhibitions. From these data it is concluded that the site of action of ascosin is probably the same as that of antimycin A.

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