Add time:09/02/2019         Source:sciencedirect.com

In a previous report it has been shown that the antibiotic ascosin inhibits the cytochrome linked electron transport system at the same site as does antimycin. This antimycin sensitive site lies between coenzyme Q or cytochrome b and cytochrome c1. Both antimycin and ascosin exhibit no antibacterial activity. This inactivity of antimycin and ascosin against bacteria is due to the absence of the antimycin sensitive site from their electron transport systems. The possibilities of other factors such as impermeability and inactivation of the antibiotic by the bacteria have been eliminated.The present investigation also shows that the electron transport systems of fungi, higher plants (corn) and mammalian tissues are similar.

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