Add time:09/06/2019         Source:sciencedirect.com

A series of hetero-dinuclear CuII–ZnII complexes, [CuZnCl2L1] (1), [CuZnCl2L2] (2), [CuZnBr2L3] (3), [CuZnBr2L4(DMF)] (4), [CuZnCl2L4] (5), [CuZnCl2L5] (6), [CuZnCl2L3] (7) and [CuZnBr2L1] (8), where L1, L2, L3, L4 and L5 are the deprotonated forms of N,N′-bis(3-ethoxysalicylidene)-1,3-propanediamine (H2L1), N,N′-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine (H2L2), N,N′-bis(3-methoxysalicylidene)-1,3-propanediamine (H2L3), N,N′-bis(salicylidene)-1,3-propanediamine (H2L4) and N,N′-bis(salicylidene)-1,4-butanediamine (H2L5), respectively, have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. The complexes were tested for their urease inhibitory activity. Complexes 1 and 8 show effective urease inhibitory activity with IC50 values of 2.2 and 10.7 μM. The molecular docking study of the complexes with the Helicobacter pylori urease was performed.

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