Add time:09/01/2019 Source:sciencedirect.com
Oxyfedrine (cas 15687-41-9), 0.5 μg/ml, caused typical but long lasting sympathomimetic effects on guinea-pig atria and trachealis, rabbit atria and duodenum and rat uterus and perfused heart. These effects were antagonised by propranolol. The heart rate and blood pressure of the anaesthetised rat also showed sympathomimetic responses. There were marked differences between the actions of oxyfedrine and l-norephedrine. Oxyfedrine showed antagonism towards catecholamines on the atria, duodenum, trachea and perfused heart (at the doses which showed agonist effects) suggesting that oxyfedrine was a partial agonist at β-adrenoceptors. High doses (50 μg/ml) showed evidence of partial agonist behaviour at α-adrenoceptors and also non-specific spasmolytic activity in rabbit portal vein.
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