Add time:09/03/2019 Source:sciencedirect.com
Oxidation of 20-hydroxy-4,5-ene-7-oxotaxinine 4 derived from a natural taxoid Taxinine B (cas 18457-44-8) via four steps gave a corresponding aldehyde 5, which afforded a new dimeric taxoid 6 through regio- and stereospecific hetero Diels–Alder cycloaddition. Similar hetero Diels–Alder reaction of 4:5,6:7-diene aldehyde 13 gave two new dimeric taxoids 14 and 15. In addition, Lewis acid-catalyzed Diels–Alder reaction of 20-hydroxy-4:5,6:7-diene taxoid 12 with N-methylmaleimide led to cycloadduct exo-16 and γ-butyrolactone endo-17, while a similar Lewis acid-catalyzed Diels–Alder reaction of 12 with taxoid 7a yielded only cycloadduct exo-18. 7a and 7b, the two isomers of alcohol 4, yielded two 5-ethyl substituted derivatives 8 and 9 through highly stereoselective Michael addition in the presence of diethylaluminum chloride. The structure and stereochemistry of the dimers were established by spectroscopic experiments including 2D NMR studies.
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