Add time:09/07/2019 Source:sciencedirect.com
In order to gain information on the activity shown by α-peptide/β-sulfonamidopeptide hybrid analogs of the potent chemotactic agent fMLF-OMe, a structure–activity study is reported on N-Boc- and N-formyl tripeptide models containing an aminoalkanesulfonic acid as central residue. Directed migration (chemotaxis), superoxide anion production, and lysozyme release have been measured. The biochemical functions and the conformational properties of the new compounds are discussed and related to previously studied models containing β-residues.
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