Add time:09/25/2019         Source:sciencedirect.com

In this study, 9-hydroxy-folianin and Sucrose octaacetate (cas 126-14-7) were isolated from the seed ethanol extract of Annona cornifolia A. St. -Hil. (Annonaceae). We found that 9-hydroxy-folianin was able to inhibit several clinical strains of the pathogenic fungus Paracoccidioides brasiliensis. The minimal inhibitory concentrations of 9-hydroxy-folianin against twelve clinical strains of P. brasiliensis were found to be in the range between 3.4 and 27.7 μg mL−1 and were much more potent than the commercial antifungal trimethropin-sulfamethoxazole. P. brasiliensis isolates (Pb-18, Pb-11, Pb-01, Pb-B339, Pb-8 and Pb-18 virulent) were also susceptible to sucrose octaacetate. The growth of Candida albicans, C. tropicalis, C. parapsilosis and Cryptococcus gattii were not affected by these compounds. Sucrose octaacetate and 9-hydroxy-folianin showed no effects with amphotericin B and trimethropin-sulfamethoxazole, but they displayed a synergetic effect with itraconazole.

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