Add time:07/15/2019         Source:sciencedirect.com

A simple and effective procedure for the enantioselective synthesis of (R)- and (S)-Moprolol was described. The key step was the asymmetric synthesis of enantiopure (R)- and (S)-guaifenesin, which were synthesized from enantioenriched (R)-3-chloro-1,2-propanediol and (S)-epichlorohydrin via kinetics of hydrolysis resolution of racemic epichlorohydrin by chiral Salen-CoIII complex. The e.e. values of both the optical compounds were above 98%, and the chemical structures of the target compounds were confirmed by 1H NMR, 13C NMR, IR, and MS.

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