Add time:09/26/2019 Source:infona.pl
Pyruvate kinase M2 (PKM2) is a rate-limiting enzyme of aerobic glycolysis in cancer cells and plays important roles in cancer metabolism and growth. Here we show that vitamin K 3 and K 5 (VK 3 and VK 5 ) are relatively specific PKM2 inhibitors. VK 3 and VK 5 showed a significantly stronger potency to inhibit PKM2 than to inhibit PKM1 and PKL, 2 other isoforms of PK dominantly expressed in most adult tissues and liver. This study combined with previous reports supports that VK 3 and VK 5 have potential as adjuvant for cancer chemotherapy.
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