Add time:07/15/2019 Source:sciencedirect.com
The new multicomponent reaction has been found: the pyridine or triethylamine catalyzed multicomponent transformation of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and 3-trifluoromethyl-2-pyrazolin-5-one results in efficient formation of the earlier unknown substituted 2,4-diamino-5-[5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-4-yl]-5H-chromeno[2,3-b]pyridine-3-carbonitriles in 58–92% yields. This new process opens a facile and efficient way to the new type of functionalized 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold, containing the 3-trifluoromethyl-2-pyrazolin-5-one fragment, which are promising compounds for different biomedical applications.
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